Wang Guangbin, Han Yaxin
Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Orthopedics, First Affiliated Hospital of China Medical University, Shenyang, China.
Comput Methods Programs Biomed. 2021 Mar;200:105862. doi: 10.1016/j.cmpb.2020.105862. Epub 2020 Nov 23.
Magnetic resonance imaging (MRI) has been known to replace computed tomography (CT) for bone and skeletal joint examination. The accurate automatic segmentation of bone structure in shoulder MRI is important for the measurement and diagnosis of bone injury and disease. Existing bone segmentation algorithms cannot achieve automatic segmentation without any prior knowledge, and their versatility and accuracy are relatively low. Therefore, an automatic segmentation combining pulse coupled neural network (PCNN) and full convolutional neural networks (FCN) is proposed.
By constructing the block-based AlexNet segmentation model and U-Net-based bone segmentation module, we implemented the humeral segmentation model, articular bone segmentation model, humeral head and articular bone segmentation model synthesis model. We use this four kinds of segmentation models to obtain candidate bone regions, and accurately detect the positions of humerus and articular bone by voting. Finally, we perform an AlexNet segmentation model in the detected bone area in one step to segment accuracy at the pixel level.
The experimental data came from 8 groups of patients in Shengjing Hospital affiliated to China Medical University. The scanning volume of each group is approximately 100 images. Five fold cross-validations and for training were recorded, and five sets of data were carefully separated. After using our technique in the three groups of patients tested, the positive predictive value of dice coefficient (PPV) and the average accuracy of sensitivity were very significant, which reached 0.96±0.02, 0.97±0.02 and 0.94±0.03, respectively.
The method used in the experiment in this paper is based on a small amount of patient sample data. The deep learning required for the experiment needs to be performed through 2D medical images. The shoulder segmentation data obtained in this way can be very accurate.
磁共振成像(MRI)已被公认为在骨骼和关节检查方面可替代计算机断层扫描(CT)。肩部MRI中骨骼结构的准确自动分割对于骨损伤和疾病的测量与诊断至关重要。现有的骨分割算法在没有任何先验知识的情况下无法实现自动分割,且其通用性和准确性相对较低。因此,提出了一种结合脉冲耦合神经网络(PCNN)和全卷积神经网络(FCN)的自动分割方法。
通过构建基于块的AlexNet分割模型和基于U-Net的骨分割模块,实现了肱骨分割模型、关节骨分割模型、肱骨头和关节骨分割模型合成模型。我们使用这四种分割模型来获取候选骨区域,并通过投票准确检测肱骨和关节骨的位置。最后,我们在检测到的骨区域中一步执行AlexNet分割模型,以在像素级别实现分割精度。
实验数据来自中国医科大学附属盛京医院的8组患者。每组的扫描量约为100张图像。记录了五次交叉验证并用于训练,仔细分离了五组数据。在对三组测试患者使用我们的技术后,骰子系数的阳性预测值(PPV)和灵敏度的平均准确率非常显著,分别达到0.96±0.02、0.97±0.02和0.94±0.03。
本文实验中使用的方法基于少量患者样本数据。实验所需的深度学习需要通过二维医学图像进行。以这种方式获得的肩部分割数据可以非常准确。