Zannetti Antonella, Benga Gheorghe, Brunetti Arturo, Napolitano Francesco, Avallone Luigi, Pelagalli Alessandra
Institute of Biostructure and Bioimaging, CNR, Via T. De Amicis 95, 80145 Naples, Italy.
Romanian Academy, Cluj-Napoca Branch, Strada Republicii 9, 400015 Cluj-Napoca, Romania.
Cells. 2020 Dec 13;9(12):2678. doi: 10.3390/cells9122678.
Aquaporins (AQPs) are a family of membrane water channel proteins that control osmotically-driven water transport across cell membranes. Recent studies have focused on the assessment of fluid flux regulation in relation to the biological processes that maintain mesenchymal stem cell (MSC) physiology. In particular, AQPs seem to regulate MSC proliferation through rapid regulation of the cell volume. Furthermore, several reports have shown that AQPs play a crucial role in modulating MSC attachment to the extracellular matrix, their spread, and migration. Shedding light on how AQPs are able to regulate MSC physiological functions can increase our knowledge of their biological behaviours and improve their application in regenerative and reparative medicine.
水通道蛋白（AQPs）是一类膜水通道蛋白家族，可控制渗透压驱动的水跨细胞膜运输。最近的研究集中在评估与维持间充质干细胞（MSC）生理学的生物学过程相关的液体通量调节。特别是，水通道蛋白似乎通过快速调节细胞体积来调节MSC增殖。此外，一些报告表明，水通道蛋白在调节MSC与细胞外基质的附着、其铺展和迁移中起关键作用。阐明水通道蛋白如何调节MSC的生理功能，可以增加我们对其生物学行为的了解，并改善它们在再生和修复医学中的应用。
