Promotes the Development of Ulcerative Colitis by Inducing the Autophagic Cell Death of Intestinal Epithelial.

There is a growing body of evidence which suggests that intestinal microbiota, especially (), are associated with intestinal immune disease such as ulcerative colitis (UC). The mechanism by which promotes intestinal epithelial cell (IEC) death remained undefined. Here, we investigated the potential mechanisms about how aggravates IEC death in UC. We first detected the abundance of in UC tissues and analyzed its relationship with the clinical characteristics of UC. Next, we explored whether promotes intestinal epithelial cell death and . Furthermore, we extracted lipopolysaccharide (LPS) of the and examined whether exacerbates UC LPS. Our results indicated that was abundant in UC tissues and was correlated with clinical characteristics. In addition, we demonstrated that and its LPS aggravated IEC death by promoted IEC autophagy. Furthermore, autophagy inhibitors, chloroquine (CQ), 3-methyladenine (3-MA) or Atg5 silencing prevented IEC death mediated by , which suggests may contribute to UC by activating autophagic cell death. All our results uncover a vital role of in autophagic cell death and UC, giving rise to a new sight for UC therapy by inhibiting excessive IEC autophagy and autophagic cell death.