No information is available on the clinical use of palifermin during breastfeeding. Because palifermin is a large protein molecule with a molecular weight of 16,300 Da, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. With an average half-life of 4.5 hours, the drug should be eliminated by the mother in 2 days. Because it is administered with potent chemotherapy agents, the persistence of those drugs is probably more relevant. The manufacturer recommends that breastfeeding should be discontinued during treatment with palifermin and for at least 2 weeks after the last dose.
关于聚乙二醇化重组人角质细胞生长因子 -2在母乳喂养期间的临床应用尚无可用信息。由于聚乙二醇化重组人角质细胞生长因子 -2是一种分子量为16300道尔顿的大蛋白质分子，其在乳汁中的含量可能非常低，而且由于它可能在婴儿胃肠道中被破坏，因此不太可能被吸收。该药物的平均半衰期为4.5小时，母亲应该在2天内将其清除。由于它与强效化疗药物联合使用，那些药物的持续性可能更值得关注。制造商建议在使用聚乙二醇化重组人角质细胞生长因子 -2治疗期间以及最后一剂后至少2周内停止母乳喂养。
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