促肾上腺皮质激素免疫测定在亚临床库欣综合征患者中的干扰
ADRENOCORTICOTROPIC HORMONE IMMUNOASSAY INTERFERENCE IN A PATIENT WITH SUBCLINICAL HYPERCORTISOLISM.
作者信息
Ozgen Saydam B, Adiyaman S C, Demir L, Yener S
机构信息
Dokuz Eylul University Hospital, Division of Endocrinology and Metabolism, Izmir, Turkey.
Izmir Katip Celebi University, Ataturk Training and Research Hospital, Department of Biochemistry, Izmir, Turkey.
出版信息
Acta Endocrinol (Buchar). 2020 Jul-Sep;16(3):379-382. doi: 10.4183/aeb.2020.379.
CONTEXT
Immunoassays are vulnerable to occasional analytical errors despite their sensitivity and specificity. Adrenocorticotropic hormone (ACTH) is among hormones which are vulnerable to assay interference.
OBJECTIVE
In this case report, we aimed to present a case of ACTH interference in a patient with subclinical hypercortisolism.
CASE REPORT
We present a case of subclinical hypercortisolism with unexpectedly elevated levels of ACTH in whom interference was shown by different biochemical methods.It is important for the clinician to keep in mind the possibility of interference when clinical and laboratory results are discordant. The communication between the clinician and laboratory staff is important while interpreting results. This case report shows that ACTH interference should be considered in patients with subclinical hypercortisolism who have unexpectedly high levels of adrenocorticotropic hormone.
背景
免疫测定尽管具有敏感性和特异性，但仍容易出现偶尔的分析误差。促肾上腺皮质激素（ACTH）是易受测定干扰的激素之一。
目的
在本病例报告中，我们旨在呈现一例亚临床库欣综合征患者出现ACTH干扰的病例。
病例报告
我们报告一例亚临床库欣综合征患者，其ACTH水平意外升高，通过不同生化方法显示存在干扰。当临床和实验室结果不一致时，临床医生牢记干扰的可能性很重要。在解释结果时，临床医生与实验室工作人员之间的沟通很重要。本病例报告表明，对于ACTH水平意外升高的亚临床库欣综合征患者，应考虑ACTH干扰的情况。
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