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基于网络嵌入的致病基因预测。

Pathogenic gene prediction based on network embedding.

机构信息

School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China.

School of Electrical and Information Engineering, Beijing University of Civil Engineering and Architecture, Beijing, China.

出版信息

Brief Bioinform. 2021 Jul 20;22(4). doi: 10.1093/bib/bbaa353.

Abstract

In disease research, the study of gene-disease correlation has always been an important topic. With the emergence of large-scale connected data sets in biology, we use known correlations between the entities, which may be from different sets, to build a biological heterogeneous network and propose a new network embedded representation algorithm to calculate the correlation between disease and genes, using the correlation score to predict pathogenic genes. Then, we conduct several experiments to compare our method to other state-of-the-art methods. The results reveal that our method achieves better performance than the traditional methods.

摘要

在疾病研究中,基因-疾病相关性的研究一直是一个重要的课题。随着生物学中大规模关联数据集的出现,我们利用不同数据集之间已知的实体相关性来构建生物异质网络,并提出了一种新的网络嵌入表示算法来计算疾病和基因之间的相关性,使用相关得分来预测致病基因。然后,我们进行了几项实验,将我们的方法与其他最先进的方法进行了比较。结果表明,我们的方法比传统方法具有更好的性能。

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