Department of Epidemiology, Human Genetics & Environmental Sciences, UTHealth Houston School of Public Health, Houston, TX 77030, USA.
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21202, USA.
Int J Environ Res Public Health. 2020 Dec 27;18(1):126. doi: 10.3390/ijerph18010126.
The human health impact from exposure to contaminated shorelines following an oil spill event has been investigated to some extent. However, the health risks to children have largely been characterized through the use of surveys and extrapolation from adult health outcomes. There is limited information on children's behaviors during beach play requiring assumptions made based on observations from play activities in home settings. The Beach Exposure and Child Health Study (BEACHES) quantified specific beach activities that can be used to inform human health risk assessments of children playing on beaches impacted by oil spills. The results of this study characterize children's risk of cancer from exposure to oil spill chemicals by incorporating exposure-related information collected from the BEACHES study and by assuming oral, dermal, and inhalation exposure routes. Point risk estimates are compared with a previous, similar study that applied default exposure parameter values obtained from the published literature. The point risk estimates informed by BEACHES data are one order of magnitude lower compared with the previous risk assessment, with dermal exposures the overall risk driver in both. Additional Monte Carlo simulations evaluating the BEACHES data provide ranges of health risks with the highest estimates associated with dermal and oral exposure routes.
人类在石油泄漏事件后接触受污染海岸线对健康造成的影响在一定程度上已得到研究。然而,儿童健康风险在很大程度上是通过使用调查和从成人健康结果推断来描述的。关于儿童在海滩玩耍期间的行为,信息有限,需要根据家庭环境中玩耍活动的观察结果进行假设。海滩暴露与儿童健康研究(BEACHES)量化了特定的海滩活动,可以用来为受石油泄漏影响的海滩上玩耍的儿童的人类健康风险评估提供信息。这项研究的结果通过纳入从 BEACHES 研究中收集的与暴露相关的信息,并假设口服、皮肤和吸入暴露途径,来描述儿童因接触石油泄漏化学物质而患癌症的风险。点风险估计值与之前应用从已发表文献中获得的默认暴露参数值的类似研究进行了比较。BEACHES 数据提供的点风险估计值比以前的风险评估低一个数量级,在这两个研究中,皮肤暴露都是整体风险驱动因素。对 BEACHES 数据进行的额外的蒙特卡罗模拟评估提供了健康风险范围,最高估计值与皮肤和口服暴露途径有关。