Bo Bing, Zhou Yang, Zheng Qingyun, Wang Guandong, Zhou Ke, Wei Jianshe
School of Physical Education, Henan University, Kaifeng 475001, Henan, China.
Sports Reform and Development Research Center, Henan University, Kaifeng 475001, Henan, China.
Biomolecules. 2020 Dec 27;11(1):19. doi: 10.3390/biom11010019.
The leading cause of heart failure is cardiomyopathy and damage to the cardiomyocytes. Adult mammalian cardiomyocytes have the ability to regenerate, but this cannot wholly compensate for myocardial cell loss after myocardial injury. Studies have shown that exercise has a regulatory role in the activation and promotion of regeneration of healthy and injured adult cardiomyocytes. However, current research on the effects of aerobic exercise in myocardial regeneration is not comprehensive. This review discusses the relationships between aerobic exercise and the regeneration of cardiomyocytes with respect to complex molecular and cellular mechanisms, paracrine factors, transcriptional factors, signaling pathways, and microRNAs that induce cardiac regeneration. The topics discussed herein provide a knowledge base for physical activity-induced cardiomyocyte regeneration, in which exercise enhances overall heart function and improves the efficacy of cardiac rehabilitation.
心力衰竭的主要原因是心肌病和心肌细胞损伤。成年哺乳动物心肌细胞具有再生能力，但这无法完全补偿心肌损伤后心肌细胞的损失。研究表明，运动对健康和受损成年心肌细胞的再生激活和促进具有调节作用。然而，目前关于有氧运动对心肌再生影响的研究并不全面。本综述从诱导心脏再生的复杂分子和细胞机制、旁分泌因子、转录因子、信号通路以及微小RNA等方面，探讨了有氧运动与心肌细胞再生之间的关系。本文讨论的主题为体育活动诱导的心肌细胞再生提供了知识基础，其中运动可增强整体心脏功能并提高心脏康复效果。
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