什么是 T+？示踪剂、阈值和地形的戈尔迪乌姆之结。

What Is T+? A Gordian Knot of Tracers, Thresholds, and Topographies.

机构信息

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia.

出版信息

J Nucl Med. 2021 May 10;62(5):614-619. doi: 10.2967/jnumed.120.245423. Epub 2020 Dec 31.

DOI:10.2967/jnumed.120.245423

PMID:33384320

Abstract

In this review we examine, in the context of the amyloid, tau, and neurodegeneration framework, the available evidence and potential alternatives on how to establish tau positivity (T+) for multiple tau-imaging tracers in order to reach a consensus on normal and abnormal tau imaging values that can be universally implemented in clinical research and therapeutic trials.

摘要

在这篇综述中，我们在淀粉样蛋白、tau 和神经退行性变框架的背景下，检查了如何为多种 tau 成像示踪剂建立 tau 阳性（T+）的现有证据和潜在替代方法，以便就可普遍应用于临床研究和治疗试验的正常和异常 tau 成像值达成共识。