Rybalko Andrey, Pytal Anna, Kaabak Mikhail, Rappoport Nadejda, Bidzhiev Anuar, Lastovka Vasilii
Intensive Care Unit, National Medical Research Center for Children's Health, Moscow, Russia.
Organ Transplantation Department, National Medical Research Center for Children's Health, Moscow, Russia.
Front Pediatr. 2020 Dec 15;8:593123. doi: 10.3389/fped.2020.593123. eCollection 2020.
The combination of extracorporeal membrane oxygenation (ECMO) and extracorporeal blood purification in children is rarely used due to small total blood volumes, risks of hemodynamic instability and a negative association between volume of blood transfusion and patient outcome. To our knowledge, this is the first description of a multimodal extracorporeal detoxication in the setting of ECMO in a post-kidney-transplant child on immunosuppression. We describe a case of a 30-months old child, who was extracorporeally resuscitated after cardiac arrest during kidney transplantation surgery and additionally treated with a number of extracorporeal blood purification methods (plasma exchange, CytoSorb, and lipopolysaccharide adsorption) in the setting of immunosuppression therapy. This case report shows the successful use of multimodal extracorporeal therapies for a good patient outcome. The lack of response to CytoSorb therapy might suggest an occult infection and not necessarily failure of treatment.
由于儿童总血容量小、存在血流动力学不稳定风险以及输血体积与患者预后呈负相关,体外膜肺氧合(ECMO)与体外血液净化在儿童中的联合应用很少使用。据我们所知,这是首次描述在接受免疫抑制治疗的肾移植后儿童中,在ECMO背景下进行多模式体外解毒。我们描述了一例30个月大的儿童,该儿童在肾移植手术中心脏骤停后接受了体外复苏,并在免疫抑制治疗背景下额外接受了多种体外血液净化方法(血浆置换、CytoSorb和脂多糖吸附)治疗。本病例报告显示多模式体外治疗成功应用并取得了良好的患者预后。对CytoSorb治疗无反应可能提示存在隐匿性感染,而不一定是治疗失败。