Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06520-8114, USA.
Baker Laboratory of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853-1301, USA.
Protein J. 2021 Apr;40(2):140-147. doi: 10.1007/s10930-020-09954-5. Epub 2021 Jan 5.
The analytical expression for the Voigt profile, along with its simplified forms for the Gaussian and Lorentzian dominance, is presented. The applicability of the Voigt profile in the description of anomalous diffusion phenomena, ubiquitous in different fields of science including protein folding, is discussed. It is shown that the Voigt profile is a good descriptor of the processes occurring in protein folding and in the native state. The usefulness of the Voigt profile in deriving important information of the diffusive motions in proteins from a quasielastic incoherent neutron scattering experiments is illustrated.
呈现了 Voigt 轮廓的解析表达式,以及其在高斯和洛伦兹主导下的简化形式。讨论了 Voigt 轮廓在描述异常扩散现象中的适用性,这种现象普遍存在于包括蛋白质折叠在内的不同科学领域。结果表明,Voigt 轮廓是描述蛋白质折叠和天然状态中发生过程的良好描述符。Voigt 轮廓在从准弹性非相干中子散射实验中得出蛋白质扩散运动的重要信息方面的有用性得到了说明。