精液生成、分析开始和 IUI 之间的时间间隔显著影响临床妊娠和活产。
Time intervals between semen production, initiation of analysis, and IUI significantly influence clinical pregnancies and live births.
机构信息
Centre for Reproductive Medicine, Antwerp University Hospital, Wilrijkstraat 10, 2650, Edegem, Belgium.
Department of Reproductive Medicine, Antwerp Surgical Training, Anatomy and Research Centre (ASTARC), Faculty of Medicine and Health Sciences, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium.
出版信息
J Assist Reprod Genet. 2021 Feb;38(2):421-428. doi: 10.1007/s10815-020-02020-0. Epub 2021 Jan 5.
PURPOSE
Does IDEF mapping help monitor the technical process of IUI and explore the potential improvements which might contribute to increased pregnancy and live birth rates?
METHOD
Retrospective analysis of 1729 homologous IUI cycles of couples attending a fertility clinic in a university hospital setting. Standardized conventional semen parameters were analyzed and the semen samples prepared via discontinuous density gradient centrifugation.
RESULTS
There was no significant association between sperm concentration, motility and morphology (analysis phase), and pregnancy outcome. Only female and male ages were significantly associated with the pregnancy outcome. There was a significant difference in the odds on clinical pregnancies and live births when analysis was ≤ 21 min initiated, and < 107 min between sample production and IUI, adjusted for male and female age.
CONCLUSIONS
Adjusting for the couple's age, we could show that time intervals between semen production and analysis and IUI when kept low significantly influenced clinical pregnancies and live births.
目的
IDEF 映射是否有助于监测 IUI 的技术过程，并探讨可能提高妊娠率和活产率的潜在改进？
方法
对在大学医院生育诊所就诊的夫妇的 1729 个同源 IUI 周期进行回顾性分析。分析了标准化的常规精液参数，并通过不连续密度梯度离心法制备精液样本。
结果
精子浓度、活力和形态（分析阶段）与妊娠结局之间无显著相关性。只有女性和男性的年龄与妊娠结局显著相关。当分析开始时间≤21 分钟且样本制备和 IUI 之间的时间<107 分钟时，临床妊娠和活产的几率有显著差异，调整了男女年龄因素。
结论
在调整夫妇年龄的情况下，我们可以表明，保持低的精液产生和分析以及 IUI 之间的时间间隔显著影响临床妊娠和活产。
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