委内瑞拉马脑炎病毒感染后血清和纹状体游离氨基酸的变化。

Changes in serum and striatal free amino acids after Venezuelan equine encephalomyelitis virus infection.

作者信息

Bonilla E, Prasad A L, Estévez J, Hernández H, Arrieta A

机构信息

Instituto de Investigaciones Clínicas, Universidad del Zulia and Inbiomed-Fundacite, Maracaibo, Venezuela.

出版信息

Exp Neurol. 1988 Mar;99(3):647-54. doi: 10.1016/0014-4886(88)90181-1.

DOI:10.1016/0014-4886(88)90181-1

PMID:3342847

Abstract

The infection with the Venezuelan equine encephalomyelitis virus produced a significant increase in the concentration of alanine, arginine, asparagine, glutamine, isoleucine, leucine, methionine, phenylalanine, threonine, tryptophan, tyrosine, and valine in the striatum of rats. On the contrary, the concentrations of aspartate, GABA, glutamate, and taurine were reduced. Arginine, aspartate, glycine, methionine, phenylalanine, taurine, and tyrosine concentrations were increased in the serum of infected rats. However, the modifications in the content of free amino acids in the striatum and serum of rats that survived the infection were qualitatively and quantitatively different from those detected during the acute phase of the infection.

摘要

委内瑞拉马脑炎病毒感染使大鼠纹状体中丙氨酸、精氨酸、天冬酰胺、谷氨酰胺、异亮氨酸、亮氨酸、蛋氨酸、苯丙氨酸、苏氨酸、色氨酸、酪氨酸和缬氨酸的浓度显著增加。相反，天冬氨酸、γ-氨基丁酸、谷氨酸和牛磺酸的浓度降低。感染大鼠血清中精氨酸、天冬氨酸、甘氨酸、蛋氨酸、苯丙氨酸、牛磺酸和酪氨酸的浓度增加。然而，感染后存活大鼠纹状体和血清中游离氨基酸含量的变化在质量和数量上与感染急性期检测到的不同。