原发性进行性失语症的分类学和语言神经病理学。
Nosology of Primary Progressive Aphasia and the Neuropathology of Language.
机构信息
Mesulam Center for Cognitive Neurology and Alzheimer's Disease; Department of Neurology, Northwestern University, Chicago, IL, USA.
Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Chicago, IL, USA.
出版信息
Adv Exp Med Biol. 2021;1281:33-49. doi: 10.1007/978-3-030-51140-1_3.
Abstract
Primary progressive aphasia (PPA) is a dementia syndrome associated with several neuropathologic entities, including Alzheimer's disease (AD) and all major forms of frontotemporal lobar degeneration (FTLD). It is classified into subtypes defined by the nature of the language domain that is most impaired. The asymmetric neurodegeneration of the hemisphere dominant for language (usually left) is one consistent feature of all PPA variants. This feature offers unique opportunities for exploring mechanisms of selective vulnerability in neurodegenerative diseases and the neuroanatomy of language. This chapter reviews some of the current trends in PPA research as well as the challenges that remain to be addressed on the nosology, clinicopathologic correlations, and therapy of this syndrome.
摘要
原发性进行性失语症（PPA）是一种与多种神经病理学实体相关的痴呆综合征，包括阿尔茨海默病（AD）和所有主要形式的额颞叶变性（FTLD）。它被分为以下几种亚型，这些亚型由语言域中最受损的语言性质来定义。语言优势半球（通常是左侧）的非对称神经退行性变是所有 PPA 变体的一个一致特征。这一特征为探索神经退行性疾病的选择性脆弱性机制和语言的神经解剖学提供了独特的机会。本章回顾了 PPA 研究的一些当前趋势，以及在该综合征的分类学、临床病理相关性和治疗方面仍有待解决的挑战。
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3
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