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[2020年美国结肠和直肠外科医师协会直肠癌管理临床实践指南解读]

[Interpretation of the 2020 American society of colon and rectal surgeons clinical practice guidelines for the management of rectal cancer].

作者信息

Wang J P

机构信息

Department of Colorectal Surgery, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, China.

出版信息

Zhonghua Wei Chang Wai Ke Za Zhi. 2021 Jan 25;24(1):27-34. doi: 10.3760/cma.j.cn.441530-20201218-00664.

Abstract

Located in the pelvic cavity and contiguous to the anal sphincter complex and urogenital organs, the rectum has more intricate anatomical features compared with the colon. Consequently, the treatment of rectal cancer involves more consideration, including pelvic radiation, lateral lymph node dissection, transanal access, postoperative function, sphincter preservation, and nonoperative management. Based on the last set of American society of colon and rectal surgeons (ASCRS) practice parameters for the management of rectal cancer published in 2013, the 2020 guidelines present evidence-based updates for both long-existing and emerging controversies on surgical management of rectal cancer. These updates include the indication for local resection, lymph node dissection for radical proctectomy, minimally invasive surgery, the "watch and wait" strategy for patients with clinical complete response, and prevention of anastomotic leak. Meanwhile, the guidelines recommend a risk-stratified approach for perioperative therapies for non-metastatic disease, and an individualized multimodality treatment based on treatment intent for synchronous metastatic disease.

摘要

直肠位于盆腔内,与肛门括约肌复合体及泌尿生殖器官相邻,与结肠相比,其解剖结构更为复杂。因此,直肠癌的治疗需要更多的考量,包括盆腔放疗、侧方淋巴结清扫、经肛门入路、术后功能、括约肌保留以及非手术治疗。基于美国结直肠外科医师协会(ASCRS)于2013年发布的最后一套直肠癌管理实践参数,2020年指南针对直肠癌手术管理中长期存在及新出现的争议给出了循证更新。这些更新包括局部切除的适应证、根治性直肠切除术的淋巴结清扫、微创手术、临床完全缓解患者的“观察等待”策略以及吻合口漏的预防。同时,指南推荐对非转移性疾病采用风险分层的围手术期治疗方法,对同步转移性疾病根据治疗意图采用个体化多模式治疗。

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