Guangdong Laboratory of Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, 510642, China.
Guangdong Laboratory of Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, 510642, China.
Trends Endocrinol Metab. 2021 Mar;32(3):159-169. doi: 10.1016/j.tem.2020.12.003. Epub 2021 Jan 15.
Butyrate, a main product of gut microbial fermentation, has been recognized as an important mediator of gut microbiota regulation in whole body energy homeostasis. However, the mechanisms of butyrate metabolic control remain unclear. This review summarizes studies that directly examined the effects of butyrate on metabolic health. The effects of butyrate on metabolic functions, including thermogenesis, lipid and glucose metabolism, appetite, inflammation, and influence on gut microbiota, are described. The effects of butyrate on cellular systems via G protein-coupled receptors (GPRs), as a histone deacetylase inhibitor, and as a substrate that is metabolized intercellularly, are also discussed. Hopefully, a better understanding of butyrate metabolic regulation may provide new perspectives for the nutritional prevention and treatment of metabolic diseases.
丁酸是肠道微生物发酵的主要产物，已被认为是调节全身能量平衡中肠道微生物群的重要介质。然而，丁酸代谢调控的机制尚不清楚。本综述总结了直接研究丁酸对代谢健康影响的研究。描述了丁酸对代谢功能的影响，包括产热、脂质和葡萄糖代谢、食欲、炎症以及对肠道微生物群的影响。还讨论了丁酸通过 G 蛋白偶联受体 (GPRs) 作为组蛋白去乙酰化酶抑制剂以及作为细胞间代谢的底物对细胞系统的影响。希望更好地了解丁酸代谢调控可能为代谢性疾病的营养预防和治疗提供新的视角。
