Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, University Putra Malaysia (UPM), UPM Serdang, Seri Kembangan 43400, Selangor, Malaysia.
Research Center of Excellence Nutrition and Non-Communicable Diseases, Faculty of Medicine and Health Sciences, University Putra Malaysia (UPM), UPM Serdang, Seri Kembangan 43400, Selangor, Malaysia.
Int J Environ Res Public Health. 2021 Jan 19;18(2):827. doi: 10.3390/ijerph18020827.
Evidence is growing that a high-acid diet might accelerate the rate of bone loss, and gene polymorphisms such as Interleukin 6 () -174G/C and -572G/C are related to bone deterioration. However, no study of the interaction between diet and polymorphisms has been conducted among Asians. Thus, the objective of this study was to determine whether IL6 gene polymorphisms modified the association between dietary acidity and the rate of bone resorption.
This cross-sectional study recruited 203 postmenopausal women (age ranged from 51 to 85 years old) in community settings. The dietary intakes of the participants were assessed using a validated interviewer-administered semi-quantitative food frequency questionnaire (FFQ), while dietary acid load (DAL) was estimated using net endogenous acid production (NEAP). Agena MassARRAY genotyping analysis and serum collagen type 1 cross-linked C-telopeptide (CTX1) were used to identify the genotype and as a bone resorption marker, respectively. The interactions between diet and single-nucleotide polymorphisms (SNPs) were assessed using linear regressions.
A total of 203 healthy postmenopausal women aged between 51 and 85 years participated in this study. The mean BMI of the participants was 24.3 kg/m. In -174 G/C, all the participants carried the GG genotype, while the C allele was absent. Approximately 40% of the participants had a high dietary acid load. Dietary acid load (B = 0.15, = 0.031) and the -572 CC genotype group (B = 0.14, = 0.044) were positively associated with a higher bone resorption. However, there was no moderating effect of the genetic polymorphism on the relationship between and acid ash diet and bone resorption markers among the postmenopausal women ( = 0.79).
High consumption of an acid ash diet and the -572 C allele seem to attribute to high bone resorption among postmenopausal women. However, our finding does not support the interaction effect of dietary acidity and (-174G/C and -572G/C) polymorphisms on the rate of bone resorption. Taken together, these results have given scientific research other candidate genes to focus on which may interact with DAL on bone resorption, to enhance planning for preventing or delaying the onset of osteoporosis among postmenopausal women.
有证据表明，高酸饮食可能会加速骨质流失速度，而白细胞介素 6（IL-6）-174G/C 和-572G/C 等基因多态性与骨恶化有关。然而，目前还没有针对亚洲人群的饮食与基因多态性相互作用的研究。因此，本研究旨在确定 IL6 基因多态性是否会改变饮食酸度与骨吸收率之间的关联。
本横断面研究在社区环境中招募了 203 名绝经后妇女（年龄 51 至 85 岁）。采用经过验证的访谈员管理半定量食物频率问卷（FFQ）评估参与者的饮食摄入量，同时使用净内源性酸生成（NEAP）估计饮食酸负荷（DAL）。采用 Agena MassARRAY 基因分型分析和血清型胶原 1 交联 C 端肽（CTX1）分别鉴定基因型和作为骨吸收标志物。使用线性回归评估饮食和单核苷酸多态性（SNP）之间的相互作用。
共有 203 名年龄在 51 至 85 岁之间的健康绝经后妇女参加了这项研究。参与者的平均 BMI 为 24.3kg/m。在-174 G/C 中，所有参与者均携带 GG 基因型，而 C 等位基因不存在。大约 40%的参与者饮食酸负荷较高。饮食酸负荷（B=0.15，=0.031）和-572 CC 基因型组（B=0.14，=0.044）与较高的骨吸收呈正相关。然而，在绝经后妇女中，基因多态性对与酸灰饮食和骨吸收标志物之间的关系没有调节作用（=0.79）。
高酸灰饮食和-572 C 等位基因的大量摄入似乎导致绝经后妇女骨吸收增加。然而，我们的发现并不支持饮食酸度和 IL-6（-174G/C 和-572G/C）多态性对骨吸收率的相互作用效应。综上所述，这些结果为科学研究提供了其他候选基因，这些基因可能与 DAL 相互作用影响骨吸收，从而有助于为绝经后妇女预防或延缓骨质疏松症的发生制定计划。
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