Pan Qiaowei, Feron Romain, Jouanno Elodie, Darras Hugo, Herpin Amaury, Koop Ben, Rondeau Eric, Goetz Frederick W, Larson Wesley A, Bernatchez Louis, Tringali Mike, Curran Stephen S, Saillant Eric, Denys Gael Pj, von Hippel Frank A, Chen Songlin, López J Andrés, Verreycken Hugo, Ocalewicz Konrad, Guyomard Rene, Eche Camille, Lluch Jerome, Roques Celine, Hu Hongxia, Tabor Roger, DeHaan Patrick, Nichols Krista M, Journot Laurent, Parrinello Hugues, Klopp Christophe, Interesova Elena A, Trifonov Vladimir, Schartl Manfred, Postlethwait John, Guiguen Yann
INRAE, LPGP, Rennes, France.
Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland.
Elife. 2021 Jan 28;10:e62858. doi: 10.7554/eLife.62858.
The understanding of the evolution of variable sex determination mechanisms across taxa requires comparative studies among closely related species. Following the fate of a known master sex-determining gene, we traced the evolution of sex determination in an entire teleost order (Esociformes). We discovered that the northern pike () master sex-determining gene originated from a 65 to 90 million-year-old gene duplication event and that it remained sex linked on undifferentiated sex chromosomes for at least 56 million years in multiple species. We identified several independent species- or population-specific sex determination transitions, including a recent loss of a Y chromosome. These findings highlight the diversity of evolutionary fates of master sex-determining genes and the importance of population demographic history in sex determination studies. We hypothesize that occasional sex reversals and genetic bottlenecks provide a non-adaptive explanation for sex determination transitions.
了解不同分类群中可变性别决定机制的进化需要对近缘物种进行比较研究。通过追踪一个已知的主性别决定基因的命运，我们追溯了整个硬骨鱼目（狗鱼目）性别决定的进化过程。我们发现，白斑狗鱼的主性别决定基因起源于6500万至9000万年前的基因复制事件，并且在多个物种中，它在未分化的性染色体上保持性连锁至少5600万年。我们确定了几个独立的物种或种群特异性性别决定转变，包括最近Y染色体的丢失。这些发现突出了主性别决定基因进化命运的多样性以及种群人口历史在性别决定研究中的重要性。我们假设，偶尔的性反转和遗传瓶颈为性别决定转变提供了一个非适应性解释。
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