（萝芙木）钩藤心材提取物的抗糖尿病作用。
Antidiabetic effects of (Lour.) corner heartwood extract.
作者信息
Chewchinda Savita, Leakaya Nantakarn, Sato Hitoshi, Sato Vilasinee Hirunpanich
机构信息
Department of Food Chemistry, Faculty of Pharmacy, Mahidol University, Bangkok, 10400, Thailand.
Division of Pharmacokinetics and Pharmacodynanics, Department of Pharmacology, Therapeutics and Toxicology, School of Pharmacy, Showa University, Tokyo, 142-8555, Japan.
出版信息
J Tradit Complement Med. 2019 Oct 22;11(1):68-74. doi: 10.1016/j.jtcme.2019.10.004. eCollection 2021 Jan.
BACKGROUND AND AIM
(MC) (Lour.) heartwood extract have been used traditionally to treat diabetes in Thailand, but their mechanism of action has not been elucidated.
EXPERIMENTAL PROCEDURE
This study investigated the effects of an aqueous heartwood extract of MC on α-glucosidase and α-amylase activities. Moreover, its antidiabetic effect was evaluated using an oral glucose tolerance test (OGTT) and a 28-day administration to streptozotocin (STZ)-nicotinamide (NA)-induced type 2 diabetic mice.
RESULTS
In both OGTT and the daily oral administration for 28 days in STZ-NA-induced type 2 diabetic mice models, the extract (1,000 mg/kg) significantly decreased fasting blood glucose. This hypoglycemic effect was explained by increased insulin levels and α-glucosidase inhibition (IC:1.53 ± 0.03 μg/mL).
CONCLUSION
This first study on the hypoglycemic activity of MC heartwood extract indicates that it could be a potential natural remedy for type 2 diabetes.
背景与目的
泰国传统上使用（MC）（Lour.）心材提取物治疗糖尿病，但其作用机制尚未阐明。
实验步骤
本研究调查了MC心材水提取物对α-葡萄糖苷酶和α-淀粉酶活性的影响。此外，通过口服葡萄糖耐量试验（OGTT）以及对链脲佐菌素（STZ）-烟酰胺（NA）诱导的2型糖尿病小鼠进行28天给药，评估了其抗糖尿病作用。
结果
在OGTT以及对STZ-NA诱导的2型糖尿病小鼠模型进行28天每日口服给药的实验中，提取物（1000mg/kg）显著降低了空腹血糖。这种降血糖作用可通过胰岛素水平升高和α-葡萄糖苷酶抑制作用（IC：1.53±0.03μg/mL）来解释。
结论
这项关于MC心材提取物降血糖活性的首次研究表明，它可能是2型糖尿病的一种潜在天然疗法。
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