Alreja Dalip, Rao Jyoti R, Kataria Sakshi, Faterpenkar Dhaval A
Department of Periodontics, Goa Dental College and Hospital, Panjim, Goa, India.
Department of Public Health Dentistry, Sudha Rustagi College of Dental Sciences and Research, Faridabad, Haryana, India.
Euroasian J Hepatogastroenterol. 2020 Jul-Dec;10(2):51-55. doi: 10.5005/jp-journals-10018-1320.
To assess the effect of nonsurgical treatment on salivary hepatocyte growth factor (sHGF) levels in a population with periodontal disease: a quasi-experimental study.
Eighty-one patients (aged 30-70 years) were divided into three groups based on the gingival index, probing depth, clinical attachment loss, and radiographic evidence of bone loss: healthy (group I), gingivitis (group II), and chronic periodontitis (group III). Saliva samples were collected from these groups at baseline. At 8 weeks, saliva samples were collected again from group II and group III after the patients went through nonsurgical periodontal treatment. The levels of HGF were estimated using enzyme-linked immunosorbent assay (ELISA). The clinical parameters and HGF levels among all groups were analyzed using a one-way analysis of variance (ANOVA) using SPSS 17 version.
At baseline, the highest mean HGF concentration in saliva was observed for group III (3455.83 ± 1463.44 pg/mL), and the least in group I (469.43 ± 317.13 pg/mL). Following nonsurgical periodontal treatment, the mean HGF concentration decreased significantly in group III and group II ( < 0.05). A significant positive correlation between clinical parameters and HGF levels was also seen ( < 0.05).
HGF concentration showed a positive correlation with the progression of periodontal disease.
Following nonsurgical periodontal therapy, the levels of HGF decreased significantly, suggesting that HGF could be useful for monitoring the response to periodontal therapy.
Alreja D, Rao JR, Kataria S, Effect of Nonsurgical Treatment on Salivary HGF Levels in Population with Periodontal Disease: A Quasi-experimental Study. Euroasian J Hepato-Gastroenterol 2020;10(2):51-55.
评估非手术治疗对牙周病患者唾液中肝细胞生长因子（sHGF）水平的影响：一项准实验研究。
根据牙龈指数、探诊深度、临床附着丧失以及骨丧失的影像学证据，将81例年龄在30至70岁之间的患者分为三组：健康组（I组）、牙龈炎组（II组）和慢性牙周炎组（III组）。在基线时从这些组中采集唾液样本。8周时，II组和III组患者接受非手术牙周治疗后再次采集唾液样本。使用酶联免疫吸附测定（ELISA）法测定HGF水平。使用SPSS 17版本通过单因素方差分析（ANOVA）对所有组的临床参数和HGF水平进行分析。
基线时，III组唾液中HGF平均浓度最高（3455.83±1463.44 pg/mL），I组最低（469.43±317.13 pg/mL）。非手术牙周治疗后，III组和II组的HGF平均浓度显著降低（<0.05）。临床参数与HGF水平之间也存在显著正相关（<0.05）。
HGF浓度与牙周病进展呈正相关。
非手术牙周治疗后，HGF水平显著降低，表明HGF可用于监测牙周治疗反应。
阿尔雷贾D，拉奥JR，卡塔里亚S，非手术治疗对牙周病患者唾液HGF水平的影响：一项准实验研究。《欧亚肝脏胃肠病学杂志》2020年；10（2）：51 - 55。
