联合生活方式因素与中国成年人健康老龄化的关系：新加坡华人健康研究。
Association Between Combined Lifestyle Factors and Healthy Ageing in Chinese Adults: The Singapore Chinese Health Study.
机构信息
Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
出版信息
J Gerontol A Biol Sci Med Sci. 2021 Sep 13;76(10):1796-1805. doi: 10.1093/gerona/glab033.
BACKGROUND
The aim of the study was to examine the relations of individual lifestyle factors and its composite score with healthy ageing among Chinese adults.
METHOD
We included 14 159 participants aged 45-74 years at baseline from the Singapore Chinese Health Study, a population-based prospective cohort. A protective lifestyle score (0-5 scale) was calculated at baseline (1993-1998) and updated at the second follow-up visit (2006-2010) on the basis of optimal body mass index (18.5-22.9 kg/m2), healthy diet (upper 40% of the Alternative Healthy Eating Index score), being physically active (≥2 h/wk of moderate activity or ≥0.5 h/wk of strenuous activity), nonsmoking (never smoking), and low-to-moderate alcohol drinking (>0 to ≤14 drinks/wk for men and >0 to ≤7 drinks/wk for women). Healthy ageing was assessed at the third follow-up visit (2014-2016) and was defined as absence of specific chronic diseases, absence of cognitive impairment and limitations in instrumental activities of daily living, good mental and overall self-perceived health, good physical functioning, and no function-limiting pain.
RESULTS
About 20.0% (2834) of the participants met the criteria of healthy ageing after a median follow-up of 20 years. Each 1-point increase in the protective lifestyle score computed at baseline and second follow-up visits was associated with higher likelihood of healthy ageing by 25% (95% CI: 20%-30%) and 24% (18%-29%), respectively. The population-attributable risk percent of adherence to 4-5 protective lifestyle factors was 34.3% (95% CI: 25.3%-42.3%) at baseline and 31.3% (23.0%-38.7%) at second follow-up visits for healthy ageing. In addition, positive increase in lifestyle scores from baseline to second follow-up visits was also significantly associated with a higher likelihood of healthy ageing with an odds ratio of 1.18 (95% CI: 1.12%-1.24%) for each increment in protective lifestyle score.
CONCLUSIONS
Our findings confirmed that adopting healthy lifestyle factors, even after midlife, was associated with healthy ageing at old age.
背景
本研究旨在探讨个体生活方式因素及其综合评分与中国成年人健康老龄化的关系。
方法
我们纳入了基线时年龄为 45-74 岁的 14159 名来自新加坡华人健康研究的参与者，这是一项基于人群的前瞻性队列研究。基于最佳体重指数（18.5-22.9kg/m2）、健康饮食（替代健康饮食指数评分的前 40%）、身体活动（每周≥2 小时中等强度活动或每周≥0.5 小时剧烈活动）、不吸烟（从不吸烟）和低至中度饮酒（男性每周>0 至≤14 份，女性每周>0 至≤7 份），在基线（1993-1998 年）和第二次随访（2006-2010 年）计算保护生活方式评分（0-5 分）。健康老龄化在第三次随访（2014-2016 年）时进行评估，定义为无特定慢性疾病、无认知障碍和日常生活活动能力受限、良好的精神和整体自我感知健康、良好的身体功能以及无功能限制的疼痛。
结果
在中位随访 20 年后，约 20.0%（2834 人）符合健康老龄化标准。在基线和第二次随访时，保护生活方式评分每增加 1 分，健康老龄化的可能性分别增加 25%（95%可信区间：20%-30%）和 24%（18%-29%）。在基线时，坚持 4-5 项保护生活方式因素的人群归因风险百分比为 34.3%（95%可信区间：25.3%-42.3%），在第二次随访时为 31.3%（23.0%-38.7%）。此外，从基线到第二次随访时生活方式评分的正向增加也与健康老龄化的可能性显著相关，保护生活方式评分每增加 1 分，比值比为 1.18（95%可信区间：1.12%-1.24%）。
结论
我们的研究结果证实，即使在中年后，采用健康的生活方式因素也与老年时的健康老龄化有关。
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