一项长达 40 年的纵向研究，旨在研究代谢综合征作为心血管疾病风险因素的作用。
A longitudinal study over 40 years to study the metabolic syndrome as a risk factor for cardiovascular diseases.
机构信息
Department of Medical Sciences, Uppsala University Hospital, Uppsala University, 751 85, Uppsala, Sweden.
The George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia.
出版信息
Sci Rep. 2021 Feb 3;11(1):2978. doi: 10.1038/s41598-021-82398-8.
The impact of most, but not all, cardiovascular risk factors decline by age. We investigated how the metabolic syndrome (MetS) was related to cardiovascular disease (CVD) during 40 years follow-up in the Uppsala Longitudinal Study of Adult Men (ULSAM, 2,123 men all aged 50 at baseline with reinvestigations at age 60, 70, 77 and 82). The strength of MetS as a risk factor of incident combined end-point of three outcomes (CVD) declined with ageing, as well as for myocardial infarction, ischemic stroke and heart failure when analysed separately. For CVD, the risk ratio declined from 2.77 (95% CI 1.90-4.05) at age 50 to 1.30 (95% CI 1.05-1.60) at age 82. In conclusion, the strength of MetS as a risk factor of incident CVD declined with age. Since MetS was significantly related to incident CVD also at old age, our findings suggest that the occurrence of MetS in the elderly should not be regarded as innocent. However, since our data were derived in an observational study, any impact of MetS in the elderly needs to be verified in a randomized clinical intervention trial.
大多数（但不是全部）心血管危险因素的影响随着年龄的增长而下降。我们在乌普萨拉男性成年人纵向研究（ULSAM，2123 名男性，基线年龄均为 50 岁，在 60 岁、70 岁、77 岁和 82 岁时进行了重新检查）中，调查了代谢综合征（MetS）在 40 年随访期间与心血管疾病（CVD）的关系。MetS 作为一种危险因素的强度与年龄相关，与三种结局（CVD）的复合终点、心肌梗死、缺血性卒中和心力衰竭的风险比均随着年龄的增长而下降。对于 CVD，风险比从 50 岁时的 2.77（95%CI 1.90-4.05）下降到 82 岁时的 1.30（95%CI 1.05-1.60）。总之，MetS 作为 CVD 发病的危险因素的强度随着年龄的增长而下降。由于 MetS 与老年人心血管事件的发生也有显著相关性，因此我们的研究结果表明，老年人出现 MetS 不应被视为无害。然而，由于我们的数据来自观察性研究，因此需要在随机临床试验中验证 MetS 在老年人中的影响。
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