猫传染性肠炎和小细胞性消化道淋巴瘤的血清触珠蛋白浓度：一种潜在的猫慢性肠病生物标志物。
Serum haptoglobin concentrations in feline inflammatory bowel disease and small-cell alimentary lymphoma: a potential biomarker for feline chronic enteropathies.
机构信息
The Cancer Institute, Animal Medical Center, New York, NY, USA.
VDI Laboratory, Simi Valley, CA, USA.
出版信息
J Feline Med Surg. 2021 Oct;23(10):959-964. doi: 10.1177/1098612X21991448. Epub 2021 Feb 5.
OBJECTIVES
The aim of this study was to evaluate serum haptoglobin as a biomarker to differentiate between small-cell alimentary lymphoma and inflammatory bowel disease in cats.
METHODS
Client-owned domestic cats with and without chronic gastrointestinal signs were enrolled in the study. Serum was collected from each patient and serum haptoglobin levels were measured using ELISA. In cats with gastrointestinal signs, histopathologic evaluation of endoscopic biopsies harvested from the intestinal tract was used to separate them into inflammatory bowel disease and small-cell lymphoma cohorts. Serum haptoglobin levels were statistically analyzed and compared among the three groups: healthy cats; cats with inflammatory bowel disease; and cats with small-cell alimentary lymphoma.
RESULTS
Sixty-two cats were enrolled in the study, including 20 clinically normal cats, 14 cats with small-cell alimentary lymphoma and 28 cats with inflammatory bowel disease. The mean ± SD serum haptoglobin was 73.2 ± 39.1 mg/dl in normal cats, 115.3 ± 72.8 mg/dl in cats with inflammatory bowel disease and 133.1 ± 86.1 mg/dl in cats with small-cell alimentary lymphoma. Cats with inflammatory bowel disease and lymphoma had significantly higher serum haptoglobin than controls, with values of 0.0382 and 0.0138, respectively. There was no statistical difference between the inflammatory bowel disease and lymphoma cohorts ( = 0.4235). For every one unit increase in serum haptoglobin, the odds of gastrointestinal inflammatory disease (inflammatory bowel disease or small-cell alimentary lymphoma) increased by 1.41% ( = 0.0165).
CONCLUSIONS AND RELEVANCE
Serum haptoglobin is a useful biomarker for distinguishing between normal cats and those with gastrointestinal inflammatory disease, but it could not significantly differentiate between inflammatory bowel disease and lymphoma. Additional studies may be beneficial in determining the prognostic significance of serum haptoglobin as it may relate to the severity of gastrointestinal inflammation.
目的
本研究旨在评估血清结合珠蛋白作为区分猫的小细胞性肠淋巴瘤和炎症性肠病的生物标志物。
方法
本研究纳入了有和无慢性胃肠道症状的患宠猫。采集每位患者的血清，并使用 ELISA 测量血清结合珠蛋白水平。对于有胃肠道症状的猫，通过对肠道内镜活检进行组织病理学评估，将其分为炎症性肠病和小细胞性肠淋巴瘤队列。对三组猫（健康猫、炎症性肠病猫和小细胞性肠淋巴瘤猫）的血清结合珠蛋白水平进行统计分析和比较。
结果
本研究共纳入 62 只猫，包括 20 只临床正常猫、14 只小细胞性肠淋巴瘤猫和 28 只炎症性肠病猫。正常猫的平均血清结合珠蛋白为 73.2 ± 39.1 mg/dl，炎症性肠病猫为 115.3 ± 72.8 mg/dl，小细胞性肠淋巴瘤猫为 133.1 ± 86.1 mg/dl。炎症性肠病和淋巴瘤猫的血清结合珠蛋白明显高于对照组， 值分别为 0.0382 和 0.0138。炎症性肠病和淋巴瘤组之间无统计学差异（ = 0.4235）。血清结合珠蛋白每增加 1 单位，胃肠道炎症性疾病（炎症性肠病或小细胞性肠淋巴瘤）的可能性增加 1.41%（ = 0.0165）。
结论和相关性
血清结合珠蛋白是区分正常猫和胃肠道炎症性疾病猫的有用生物标志物，但不能显著区分炎症性肠病和淋巴瘤。进一步的研究可能有助于确定血清结合珠蛋白作为反映胃肠道炎症严重程度的预后指标的意义。
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