Ⅰ型干扰素对细菌病原体易感性的影响。
Impact of Type I Interferons on Susceptibility to Bacterial Pathogens.
机构信息
Department of Pathology, Immunology, and Laboratory Medicine, Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ, USA.
Department of Pathology, Immunology, and Laboratory Medicine, Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ, USA.
出版信息
Trends Microbiol. 2021 Sep;29(9):823-835. doi: 10.1016/j.tim.2021.01.007. Epub 2021 Feb 2.
Abstract
Interferons (IFNs) are a broad class of cytokines that have multifaceted roles. Type I IFNs have variable effects when it comes to host susceptibility to bacterial infections, that is, the resulting outcomes can be either protective or deleterious. The mechanisms identified to date have been wide and varied between pathogens. In this review, we discuss recent literature that provides new insights into the mechanisms of how type I IFN signaling exerts its effects on the outcome of infection from the host's point of view.
摘要
干扰素（IFNs）是一类具有多种作用的细胞因子。I 型干扰素对宿主易感性细菌感染的影响是可变的，也就是说，其结果可能是保护性的，也可能是有害的。迄今为止已确定的机制在病原体之间是广泛而不同的。在这篇综述中，我们讨论了最近的文献，这些文献提供了新的见解，阐明了从宿主的角度来看，I 型 IFN 信号传导发挥其对感染结果的影响的机制。
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