年老与寒冷：一位老年女性合并司可巴比妥和戊巴比妥中毒的新病例
Old and Cold: A Novel Case of Combined Secobarbital and Pentobarbital Poisoning in an Elderly Woman.
作者信息
Katz Kenneth D, Koons Andrew, Makar Gregory, Wier Amy
机构信息
Emergency Medicine • Medical Toxicology, University of South Florida Morsani College of Medicine / Lehigh Valley Health Network, Allentown, USA.
Emergency Medicine, University of South Florida Morsani College of Medicine / Lehigh Valley Health Network, Allentown, USA.
出版信息
Cureus. 2021 Jan 3;13(1):e12446. doi: 10.7759/cureus.12446.
A 94-year-old woman was found unresponsive in her room at an independent living facility. Upon paramedic arrival, the patient had a Glasgow Coma Scale of 3, and she was transported to the emergency department (ED). In the ED, she was unresponsive but spontaneously breathing, bradycardia, and hypothermia. Serum concentrations of both secobarbital (3.3µg/mL; therapeutic 1.0-2.0µg/mL) and pentobarbital (9.5µg/mL; therapeutic < 5.0µg/mL) were detected and elevated. This type of poisoning is quite rare and should be considered in patients presenting with hypothermia and coma, even in patients showing brain death signs. The use of hemodialysis for refractory pentobarbital poisoning may be helpful.
一名94岁女性在一家独立生活设施的房间里被发现无反应。护理人员到达时，患者格拉斯哥昏迷量表评分为3分，随后被送往急诊科（ED）。在急诊科，她无反应但有自主呼吸，存在心动过缓和体温过低的情况。检测到血清司可巴比妥浓度（3.3µg/mL；治疗浓度为1.0 - 2.0µg/mL）和戊巴比妥浓度（9.5µg/mL；治疗浓度<5.0µg/mL）均升高。这种中毒类型非常罕见，对于出现体温过低和昏迷的患者，即使是表现出脑死亡迹象的患者，也应考虑这种情况。对于难治性戊巴比妥中毒，使用血液透析可能会有帮助。
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