School of Chemical Sciences, National Institute of Science Education and Research (NISER), HBNI, Bhubaneswar, PO Bhimpur-Padanpur, Via Jatni, District Khurda, Odisha 752050, India.
Dalton Trans. 2021 Feb 28;50(8):3027-3036. doi: 10.1039/d0dt03901b. Epub 2021 Feb 11.
Aluminum toxicity in biological systems is a well-known issue yet remains as a prevalent and unsolvable problem due to the lack of proper molecular tools that can detect free aluminum(iii) or Al(iii) ions in vivo. Herein, we report a water-soluble photo-induced electron transfer (PET)-based turn-ON/OFF fluorometric chemosensor for the dual detection of Al(iii) and fluoride ions in aqueous media with a nanomolar (∼1.7 × 10 M) and picomolar (∼2 × 10 M, lowest ever detection so far) detection limit, respectively. Fluoride ions in sea water could be detected as well as the recognition of non-contamination in drinking water. In addition, using live-cell microscopy, Al(iii) ions were detected in live biological samples in vivo to aid establishing the aluminum-toxicity effect.
生物体系中的铝毒性是一个众所周知的问题，但由于缺乏能够检测体内游离铝(iii)或 Al(iii)离子的适当分子工具，这个问题仍然普遍存在且无法解决。在这里，我们报告了一种水溶性光诱导电子转移（PET）基于开/关荧光化学传感器，用于在水介质中双重检测 Al(iii)和氟离子，其检测限分别为纳摩尔（∼1.7×10 M）和皮摩尔（∼2×10 M，迄今为止的最低检测限）。该传感器还可以检测海水中的氟离子，以及识别饮用水的非污染情况。此外，通过使用活细胞显微镜，在体内活生物样品中检测到 Al(iii)离子，以帮助建立铝毒性效应。
Zotero 插件