Istituto di Endocrinologia ed Oncologia Sperimentale-CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli "Federico II", Napoli 80131, Italy.
Dipartimento di Medicina di Precisione, Università della Campania "L. Vanvitelli", 80138 Napoli, Italy.
Int J Mol Sci. 2021 Jan 30;22(3):1380. doi: 10.3390/ijms22031380.
Testicular germ cell tumors (TGCTs) are the leading form of solid cancer and death affecting males between the ages of 20 and 40. Today, their surgical resection and chemotherapy are the treatments of first choice, even if sometimes this is not enough to save the lives of patients with TGCT. As seen for several tumors, the deregulation of microRNAs (miRNAs) is also a key feature in TGCTs. miRNAs are small molecules of RNA with biological activity that are released into biological fluids by testicular cancer cells. Their presence, therefore, can be detected and monitored by considering miRNAs as diagnostic and prognostic markers for TGCTs. The purpose of this review is to collect all the studies executed on miRNAs that have a potential role as biomarkers for testicular tumors.
睾丸生殖细胞肿瘤（TGCTs）是 20 至 40 岁男性中最常见的实体癌症和死亡形式。如今，手术切除和化疗是首选治疗方法，即使有时这不足以挽救 TGCT 患者的生命。正如在几种肿瘤中看到的那样，microRNAs（miRNAs）的失调也是 TGCTs 的一个关键特征。miRNAs 是具有生物活性的小分子 RNA，由睾丸癌细胞释放到生物体液中。因此，通过将 miRNAs 视为 TGCT 的诊断和预后标志物，可以检测和监测它们的存在。本综述的目的是收集所有关于具有睾丸肿瘤潜在生物标志物作用的 miRNAs 的研究。
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