哮喘儿童控制不佳与睡眠呼吸障碍的关系：一项两中心研究。
Relationship between Poorly Controlled Asthma and Sleep-Related Breathing Disorders in Children with Asthma: A Two-Center Study.
机构信息
Department of Respiratory Medicine, The Affiliated Wuxi Children's Hospital of Nanjing Medical University, Wuxi, China.
Department of Respiratory Medicine, Children's Hospital of Nanjing Medical University, Nanjing, China.
出版信息
Can Respir J. 2021 Jan 28;2021:8850382. doi: 10.1155/2021/8850382. eCollection 2021.
OBJECTIVE
Asthma and sleep-related breathing disorders (SRBD) are common chronic respiratory diseases in children. The relationship between asthma and SRDB is bidirectional. However, only a few studies have analyzed the relationship between asthma control status and risk of SRBD. The aim of this study was to evaluate the relationship between asthma control and SRBD and further assess the relationship between therapy/atopy/lung function of children with asthma and SRBD.
METHODS
A total of 209 children aged 3-16 years were enrolled in this study. Pediatric sleep questionnaire (PSQ) scores were used to identify children at high risk of developing SRBD. Data on asthma control status, therapy, allergy, lung function, and exhaled nitric oxide were collected.
RESULTS
A significantly higher risk of SRBD was found among children with poorly controlled asthma (34.25% vs. 13.97%, < 0.01) and allergic rhinitis (AR) (34.29% vs. 13.92%, < 0.01) than among children with well-controlled asthma and AR. The prevalence of SRBD was also significantly higher in asthmatic children with obesity than that with just obesity (42.11% vs. 20.00%, < 0.05). Multiple logistic regression analysis showed that poorly controlled asthma (OR, 2.746 (95% CI, 1.215-6.209); < 0.05) and poorly controlled AR (OR, 3.284 (95% CI, 1.430-7.544); < 0.01) increased the odds of having SRBD.
CONCLUSION
Poorly controlled asthma and AR increase the risk of SRBD. A routine check of the level of asthma control and appropriate use of medication for AR are important because of their influence on SRBD.
目的
哮喘和睡眠相关呼吸障碍（SRBD）是儿童常见的慢性呼吸系统疾病。哮喘和 SRBD 之间存在双向关系。然而，只有少数研究分析了哮喘控制状况与 SRBD 风险之间的关系。本研究旨在评估哮喘控制与 SRBD 之间的关系，并进一步评估儿童哮喘和 SRBD 的治疗/过敏/肺功能之间的关系。
方法
本研究共纳入 209 名 3-16 岁儿童。使用儿科睡眠问卷（PSQ）评分来确定患有 SRBD 的高风险儿童。收集哮喘控制状况、治疗、过敏、肺功能和呼出气一氧化氮的数据。
结果
与哮喘控制良好且伴有过敏的儿童相比，哮喘控制不良（34.25% vs. 13.97%， < 0.01）和伴有过敏的儿童（34.29% vs. 13.92%， < 0.01）发生 SRBD 的风险显著更高。肥胖的哮喘儿童的 SRBD 患病率也明显高于单纯肥胖的儿童（42.11% vs. 20.00%， < 0.05）。多因素逻辑回归分析显示，哮喘控制不良（OR，2.746（95%CI，1.215-6.209）； < 0.05）和哮喘控制不良（OR，3.284（95%CI，1.430-7.544）； < 0.01）增加了患有 SRBD 的几率。
结论
哮喘控制不良和哮喘控制不良增加了发生 SRBD 的风险。由于哮喘控制水平和 AR 的适当用药对 SRBD 有影响，因此常规检查哮喘控制水平和适当使用 AR 药物非常重要。
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