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单纯前路椎间融合术(ALIF)中应用同种异体骨与自体骨相结合的新型植骨技术(“诺森比亚技术”)——100 例连续患者的融合率与功能结局。

Novel bone grafting technique in stand-alone ALIF procedure combining allograft and autograft ('Northumbria Technique')-Fusion rate and functional outcomes in 100 consecutive patients.

机构信息

Wansbeck General Hospital, Woodhorn Ln, Ashington, NE63 9JJ, UK.

出版信息

Eur Spine J. 2021 May;30(5):1296-1302. doi: 10.1007/s00586-021-06758-8. Epub 2021 Feb 15.

Abstract

INTRODUCTION

Successful ALIF surgery depends upon achieving solid fusion, whilst avoiding significant complications. Herein, we present the 'Northumbria Technique' of combining allograft with autograft in order to achieve solid interbody fusion.

MATERIALS AND METHODS

A single-surgeon series of 100 consecutive patients undergoing stand-alone ALIF from 2016 to 2019 was studied. All had percutaneously harvested iliac crest bone graft (ICBG) dowels inserted into blocks of fresh frozen femoral head (FFFH) allograft, which were then inserted into the ALIF cages. Patients had dynamic radiographs at 4 months, CT at 6 months, and patient reported outcome measure scores (PROMS) throughout.

RESULTS

One hundred patients (average age 44.8 years) were followed-up for an average of 29.1 months. Ninety-four (94%) patients were assessed as having fused on both CT and radiographs by an independent Radiologist. Three (3%) patients had abolition of movement on radiographs, but either lacked a CT scan or failed to meet Williams criteria for fusion. Two patients failed to attend for any imaging, so were considered not fused, and one patient had no evidence of fusion in either modality. There was a significant improvement in all PROMS. There were no intra-operative complications, and one patient had transient donor-site pain.

CONCLUSIONS

The newly described 'Northumbria Technique' utilises the osteoconductive characteristics of the FFFH allograft, as well as the osteoinductive and osteogenic properties of the ICBG autograft. It gives high fusion rates (94-97%) and statistically significant improvements in PROMS, whilst avoiding the complications of harvesting a large amount of autograft and the huge costs of using synthetic agents.

摘要

简介

前路腰椎间融合术(ALIF)的成功取决于实现稳定融合,同时避免严重并发症。在此,我们介绍一种“诺森比亚技术”,该技术将同种异体移植物与自体移植物相结合,以实现稳定的椎间融合。

材料和方法

对 2016 年至 2019 年间 100 例接受独立前路腰椎间融合术的单外科医生系列患者进行了研究。所有患者均经皮采集髂嵴骨移植物(ICBG)栓插入新鲜冷冻股骨头(FFFH)同种异体移植物块中,然后将其插入 ALIF 笼中。患者在术后 4 个月进行动态 X 线检查,6 个月进行 CT 检查,并在整个过程中进行患者报告的结局测量评分(PROMs)。

结果

100 例患者(平均年龄 44.8 岁)平均随访 29.1 个月。94 例(94%)患者经独立放射科医生评估 CT 和 X 线均融合。3 例(3%)患者 X 线片上运动消失,但缺乏 CT 扫描或不符合融合的 Williams 标准。2 例患者未接受任何影像学检查,因此被认为未融合,1 例患者两种影像学检查均未见融合。所有 PROMs 均显著改善。术中无并发症,1 例患者出现短暂供区疼痛。

结论

新描述的“诺森比亚技术”利用了 FFFH 同种异体移植物的骨诱导特性,以及 ICBG 自体移植物的骨诱导和骨生成特性。它具有较高的融合率(94-97%)和 PROMs 的统计学显著改善,同时避免了采集大量自体移植物的并发症和使用合成制剂的巨大成本。

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