用于改善 COVID-19 和未来大流行诊断的新兴生物传感技术。
Emerging biosensing technologies for improved diagnostics of COVID-19 and future pandemics.
机构信息
Department of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen, 518060, China; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Department of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen, 518060, China.
National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, 518112, China.
出版信息
Talanta. 2021 Apr 1;225:121986. doi: 10.1016/j.talanta.2020.121986. Epub 2020 Dec 13.
Diagnostic tools play significant roles in the fight against COVID-19 and other pandemics. Existing tests, such as RT-qPCR, have limitations including long assay time, low throughput, inadequate sensitivity, and suboptimal portability. Emerging biosensing technologies hold the promise to develop tests that are rapid, highly sensitive, and suitable for point-of-care testing, which could significantly facilitate the testing of COVID-19. Despite that, practical applications of such biosensors in pandemics have yet to be achieved. In this review, we consolidate the newly developed diagnostic tools for COVID-19 using emerging biosensing technologies and discuss their application promise. In particular, we present nucleic acid tests and antibody tests of COVID-19 based on both conventional and emerging biosensing methods. We then provide perspectives on the existing challenges and potential solutions.
诊断工具在抗击 COVID-19 和其他大流行中发挥着重要作用。现有的检测方法，如 RT-qPCR，存在一些局限性，包括检测时间长、通量低、灵敏度不足和便携性不佳。新兴的生物传感技术有望开发出快速、高灵敏度且适用于即时检测的检测方法，这将极大地方便 COVID-19 的检测。尽管如此，这些生物传感器在大流行中的实际应用尚未实现。在这篇综述中，我们整合了使用新兴生物传感技术开发的 COVID-19 诊断工具，并讨论了它们的应用前景。特别地，我们介绍了基于传统和新兴生物传感方法的 COVID-19 的核酸检测和抗体检测。然后，我们提供了对现有挑战和潜在解决方案的看法。
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