甲型流感病毒的合并感染会增强 SARS-CoV-2 的感染性。

Coinfection with influenza A virus enhances SARS-CoV-2 infectivity.

机构信息

State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei, 430072, China.

Animal Biosafety Level 3 Laboratory, Wuhan University, Wuhan, Hubei, 430072, China.

出版信息

Cell Res. 2021 Apr;31(4):395-403. doi: 10.1038/s41422-021-00473-1. Epub 2021 Feb 18.

DOI:10.1038/s41422-021-00473-1

PMID:33603116

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7890106/

Abstract

The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health. Through experimental coinfection with influenza A virus (IAV) and either pseudotyped or live SARS-CoV-2 virus, we found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types. Remarkably, in vivo, increased SARS-CoV-2 viral load and more severe lung damage were observed in mice coinfected with IAV. Moreover, such enhancement of SARS-CoV-2 infectivity was not observed with several other respiratory viruses, likely due to a unique feature of IAV to elevate ACE2 expression. This study illustrates that IAV has a unique ability to aggravate SARS-CoV-2 infection, and thus, prevention of IAV infection is of great significance during the COVID-19 pandemic.

摘要

即将到来的北半球流感季节与当前的 COVID-19 大流行合并，对公共卫生构成了潜在的严重威胁。通过用甲型流感病毒（IAV）和假型或活 SARS-CoV-2 病毒进行实验性混合感染，我们发现 IAV 预先感染可显著提高 SARS-CoV-2 在广泛的细胞类型中的感染性。值得注意的是，在体内，感染 IAV 的小鼠中观察到 SARS-CoV-2 病毒载量增加和更严重的肺部损伤。此外，在感染了几种其他呼吸道病毒的小鼠中未观察到这种增强的 SARS-CoV-2 感染性，这可能是由于 IAV 升高 ACE2 表达的独特特征所致。这项研究表明，IAV 具有加重 SARS-CoV-2 感染的独特能力，因此，在 COVID-19 大流行期间预防 IAV 感染具有重要意义。