Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Sci Rep. 2021 Feb 18;11(1):4046. doi: 10.1038/s41598-021-83725-9.
This study aimed to investigate the efficacy of salt intake restriction on overactive bladder (OAB) symptoms in patients with excessive salt intake. Patients received a brochure on nutritional guidance regarding salt intake reduction and received health education every 4 weeks for 12 weeks. Data from overactive bladder symptom score (OABSS) questionnaires and frequency volume charts (FVCs) were evaluated. The daily salt intake was estimated by determining the urinary sodium and creatinine concentrations using spot urine samples. Of the 98 patients included, 71 (72.4%) successfully restricted their daily salt intake after 12 weeks (salt restricted [R] group), while 27 (27.6%) did not (salt non-restricted [N-R] group). The scores to each OABSS question and the resulting total score improved significantly in the R group; however, the individual scores remained unchanged and the total score increased in the N-R group. The FVC data indicated improved voided volumes in the R group as compared to in the N-R group. Ultimately, 17 (23.9%) patients in the R group no longer fulfilled the OAB diagnostic criteria after salt intake reduction. Thus, salt intake reduction improved urinary symptoms in patients with OAB and may be a therapeutic option for OAB in patients with excessive daily salt intakes.
本研究旨在探讨限制盐摄入量对盐摄入量过多的膀胱过度活动症(OAB)患者症状的疗效。患者接受了关于减少盐摄入量的营养指导手册,并在 12 周内每 4 周接受一次健康教育。评估了膀胱过度活动症症状评分(OABSS)问卷和频率体积图表(FVC)的数据。通过测定尿样中的尿钠和肌酐浓度来估算每日盐摄入量。在 98 名患者中,71 名(72.4%)在 12 周后成功限制了每日盐摄入量(盐限制[R]组),而 27 名(27.6%)没有(盐非限制[N-R]组)。R 组的每个 OABSS 问题的评分和总评分均显著改善;然而,N-R 组的各个评分保持不变,总评分增加。FVC 数据表明,与 N-R 组相比,R 组的排空量增加。最终,R 组中有 17 名(23.9%)患者在减少盐摄入后不再符合 OAB 的诊断标准。因此,减少盐摄入量可改善 OAB 患者的尿路症状,并且可能是每日盐摄入量过多的 OAB 患者的一种治疗选择。