Mali Kailas K, Sutar Guruprasad V, Dias Remeth J, Devade Omkar A
Adarsh College of Pharmacy, Department of Pharmacology, Vita, Maharashtra, India.
Annasaheb Dange College of B-Pharmacy, Department of Pharmacology, Astha, Maharashtra, India.
Turk J Pharm Sci. 2021 Feb 25;18(1):3-9. doi: 10.4274/tjps.galenos.2019.30316.
The present study aimed to evaluate the nootropic activity of in rats.
Methanolic extract of was used to evaluate nootropic activity, piracetam (200 mg/kg, i.p.) was used as a standard, and scopolamine (1 mg/kg, i.p.) was used to induce amnesia. The effect of drugs on learning and memory in rats was evaluated by using the Y-maze task and elevated plus maze on scopolamine-induced amnesia models. Locomotor activity was performed using an actophotometer. Also, levels of acetylcholinestrease, including histopathological examination of rat brains, were assessed.
Methanolic extract of showed increased alteration of the behavior response and percentage spontaneous alteration with the Y-maze task. In the elevated plus maze scopolamine-induced amnesia model, methanolic extract of showed a decrease in transfer latency, which is indicative of cognition improvement. Methanolic extract increased locomotor activity in rats and decreased the levels of acetylcholinestrease enzyme significantly. A histopathological study with both low and high doses of extract showed effective regenerative scores as compared to normal control, negative control and standard treatment.
The results suggested that the administration of methanolic extract of enhances learning and memory in different experimental models. The histopathological study revealed the neuroprotective property of the extract. The study indicates that the extract may be used in the treatment of Alzheimer's disease.
本研究旨在评估[具体物质名称未给出]在大鼠中的益智活性。
使用[具体物质名称未给出]的甲醇提取物评估益智活性，吡拉西坦（200毫克/千克，腹腔注射）用作标准品，东莨菪碱（1毫克/千克，腹腔注射）用于诱导失忆。通过在东莨菪碱诱导的失忆模型上使用Y迷宫任务和高架十字迷宫来评估药物对大鼠学习和记忆的影响。使用活动光度计进行运动活性测试。此外，还评估了乙酰胆碱酯酶水平，包括对大鼠大脑的组织病理学检查。
[具体物质名称未给出]的甲醇提取物在Y迷宫任务中显示出行为反应改变增加和自发改变百分比增加。在高架十字迷宫东莨菪碱诱导的失忆模型中，[具体物质名称未给出]的甲醇提取物显示转移潜伏期缩短，这表明认知能力得到改善。甲醇提取物增加了大鼠的运动活性，并显著降低了乙酰胆碱酯酶的水平。与正常对照、阴性对照和标准治疗相比，低剂量和高剂量提取物的组织病理学研究均显示出有效的再生评分。
结果表明，给予[具体物质名称未给出]的甲醇提取物可增强不同实验模型中的学习和记忆能力。组织病理学研究揭示了该提取物的神经保护特性。该研究表明该提取物可用于治疗阿尔茨海默病。
