弥漫特发性肺神经内分泌细胞增生症（DIPNECH）的治疗进展。

An Update on the Management of Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH).

机构信息

Department of GI Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, 33612, USA.

Neuroendocrine Tumor Unit, ENETS Center of Excellence, Department of Endocrinology and Metabolism, Hadassah-Hebrew University Medical Center, P.O.B. 12000, 91120, Jerusalem, Israel.

出版信息

Curr Treat Options Oncol. 2021 Feb 27;22(4):28. doi: 10.1007/s11864-021-00828-1.

DOI:10.1007/s11864-021-00828-1

PMID:33641079

Abstract

DIPNECH is caused by an idiopathic proliferation of pulmonary neuroendocrine cells which can lead to bronchiolitis and multifocal lung neuroendocrine tumors. Patients often present with chronic cough and dyspnea. Larger NETs may develop malignant potential. Somatostatin analogs can palliate chronic symptoms, particularly cough. Surgical resection can be considered for relatively large (e.g. >1 cm), progressive tumors.

摘要

DIPNECH 是由肺神经内分泌细胞的特发性增殖引起的，可导致细支气管炎和多灶性肺神经内分泌肿瘤。患者常表现为慢性咳嗽和呼吸困难。较大的 NET 可能有恶性潜能。生长抑素类似物可缓解慢性症状，特别是咳嗽。对于相对较大（例如 >1cm）、进展性肿瘤，可以考虑手术切除。