Gong Zi-Peng, Lin Chao-Zhan, Han Li-Wei
Department of Health Science,National Natural Science Foundation of China Beijing 100085,China Provincial Key Laboratory of Pharmaceutics in Guizhou,State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and Traditional Chinese Medicine,School of Pharmacy,Guizhou Medical University Guiyang 550004,China.
Department of Health Science,National Natural Science Foundation of China Beijing 100085,China School of Pharmaceutical Sciences,Guangzhou University of Chinese Medicine Guangzhou 510006,China.
Zhongguo Zhong Yao Za Zhi. 2021 Feb;46(4):1010-1016. doi: 10.19540/j.cnki.cjcmm.20210122.502.
The pharmacokinetics of traditional Chinese medicine is a subject that studies the dynamic changes of the absorption, distribution, metabolism and excretion of complex components of traditional Chinese medicine, which is an important method for elucidating the pharmacodynamic material basis, action characteristics, and compatibility mechanisms of traditional Chinese medicine. However, given on the fact that traditional Chinese medicine is a multi-dimensional and complex system with multiple components, multiple pathways, multiple targets, and an unclear pharmacodynamic material basis, the research on the pharmacokinetics of traditio-nal Chinese medicine has become a scientific and technological problem. Although the pharmacokinetics of traditional Chinese medicine has achieved remarkable development with the emergence of new theories, methods and technologies, there are still some problems in the application of the research direction of the pharmacokinetics of traditional Chinese medicine judging from the current application of the National Natural Science Foundation of China. Therefore, this article discussed the current research status on pharmacokinetics of traditional Chinese medicines by analyzing the projects funded by the National Natural Science Foundation of China in the past 5 years from 2016 to 2020, mainly including the application and funding analysis, main research contents of the projects in pharmacokinetics of traditional Chinese medicines. And the research hotspots, difficulties and deficiencies were focused in order to provide certain reference for researchers engaged in pharmacokinetics of traditional Chinese medicine.
中药药代动力学是研究中药复杂成分吸收、分布、代谢和排泄动态变化的学科,是阐明中药药效物质基础、作用特点及配伍机制的重要手段。然而,鉴于中药是一个具有多成分、多途径、多靶点且药效物质基础不明确的多维复杂体系,中药药代动力学研究成为一个科技难题。尽管随着新理论、方法和技术的出现,中药药代动力学取得了显著进展,但从中国国家自然科学基金目前的资助情况来看,中药药代动力学研究方向的应用仍存在一些问题。因此,本文通过分析2016年至2020年过去5年中国国家自然科学基金资助的项目,探讨了中药药代动力学的研究现状,主要包括申请与资助分析、中药药代动力学项目的主要研究内容。并重点关注了研究热点、难点及不足之处,以期为从事中药药代动力学研究的人员提供一定参考。