使用³¹P反转自旋转移技术在体内测定肿瘤中的三磷酸腺苷（ATP）

In vivo determination of ATP in tumors using 31P inversion spin transfer.

作者信息

Haseler L J, Bulliman B T, Kuchel P W, Doddrell D M, Bell J R, Irving M G

机构信息

School of Science, Griffith University, Nathan, Australia.

出版信息

Cancer Invest. 1988;6(1):47-53. doi: 10.3109/07357908809077028.

DOI:10.3109/07357908809077028

PMID:3365572

Abstract

The in vivo exchange kinetics of creatine kinase in the hind leg muscle of rats containing a transplanted mammary adenocarcinoma has been investigated using 31P magnetic resonance spectroscopy. Using a solenoid coil, the adenosine triphosphate (ATP) resonances arising from the tumor could be distinguished from ATP resonances arising from the muscle surrounding the tumor by use of inversion spin transfer techniques. This procedure affords a specific method of evaluating ATP metabolism of tumors in vivo.

摘要

利用31P磁共振波谱研究了含有移植性乳腺腺癌的大鼠后腿肌肉中肌酸激酶的体内交换动力学。使用螺线管线圈，通过反转自旋转移技术，可以将肿瘤产生的三磷酸腺苷（ATP）共振与肿瘤周围肌肉产生的ATP共振区分开来。该方法提供了一种在体内评估肿瘤ATP代谢的特定方法。