发光二极管刺激放射性皮炎的恢复。
Light-emitting diode stimulates radiodermatitis recovery.
机构信息
MD, PhD. Universidade de São Paulo - Medical School - Laboratory of Microsurgery and Plastic Surgery - São Paulo (SP), Brazil.
MD, PhD. Universidade de São Paulo - Medical School - Department of Radiology and Oncology - São Paulo (SP), Brazil.
出版信息
Acta Cir Bras. 2021 Feb 26;36(3):e360301. doi: 10.1590/ACB360301. eCollection 2021.
PURPOSE
To evaluate the effect of light-emitting diode (LED) in an experimental model of radiodermatitis.
METHODS
Ten male Wistar rats weighing 200-250 g were analyzed. Radiation was delivered in a single dose (20 Gy with Strontium-90 dermatological plaques), two areas per animal. After 15 days, they were divided into two groups: control group (n = 5) and LED group (n = 5), which was treated during 21 days later (LED 660 nm, 10 min in alternate days). The endpoints were radiodermatitis scale, histological analysis HE, Picrius Sirius and the gene expression of interleukin-10 (IL-10) and matrix metalloproteinase-9 (MMP-9).
RESULTS
The LED group showed a higher number of dermal appendages (p = 0.04) and angiogenesis(p = 0.007), a tendency towards higher IL-10 (p = 0.06) and an increase in MMP-9 (p = 0.004) when compared to the control group.
CONCLUSIONS
This study suggested that the use of LED for radiodermatitis increased skin regeneration.
目的
评估发光二极管（LED）在放射性皮炎实验模型中的作用。
方法
分析了 10 只雄性 Wistar 大鼠，体重为 200-250 克。对每个动物的两个部位给予单次剂量（20 Gy 的锶-90 皮肤科斑块照射）。15 天后，它们被分为两组：对照组（n = 5）和 LED 组（n = 5），后者在之后的 21 天内进行治疗（660nm 的 LED，隔日治疗 10 分钟）。终点是放射性皮炎评分、组织学分析 HE、苦味酸天狼猩红染色和白细胞介素 10（IL-10）和基质金属蛋白酶 9（MMP-9）的基因表达。
结果
与对照组相比，LED 组的皮肤附属物数量更高（p = 0.04），血管生成更多（p = 0.007），IL-10 呈升高趋势（p = 0.06），MMP-9 增加（p = 0.004）。
结论
本研究表明，LED 用于放射性皮炎可增加皮肤再生。
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