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越南产地衣中两个新的酚类化合物。

Two new phenolic compounds from the lichen growing in Vietnam.

机构信息

Faculty of Environmental Science, Sai Gon University, Ho Chi Minh City, Vietnam.

Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam.

出版信息

Nat Prod Res. 2022 Aug;36(15):3865-3871. doi: 10.1080/14786419.2021.1892672. Epub 2021 Mar 3.

Abstract

Two new phenolic compounds, cristiferides A-B () together with six known compounds, 2,4-dihydroxyphthalide (), lecanoric acid (), orsellinic acid (), 5-chloroorsellinic acid (), methyl haematommate (), and methyl β-orsellinate () were isolated from the lichen (Taylor) Hale (Parmeliaceae). The structures of isolated compounds were identified from its spectroscopic data and by comparison with the literatures. Compounds - and were evaluated for alpha-glucosidase inhibition. Compounds and revealed potent activity with IC values of 72.66 μM and 48.73 μM, respectively.

摘要

从地茶(Taylor)Hale(Parmeliaceae)中分离得到两种新的酚类化合物,cristiferides A-B(),以及六种已知化合物:2,4-二羟基邻苯二甲酸酐()、苔黑酚酸()、orsellinic 酸()、5-氯orsellinic 酸()、甲基血根素()和甲基β-orsellinate()。从其光谱数据和与文献的比较中确定了分离化合物的结构。对化合物 - 和 进行了α-葡萄糖苷酶抑制活性评价。化合物 和 表现出较强的活性,IC 值分别为 72.66 μM 和 48.73 μM。

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