Almasi Simin, Karbalaei Sabbagh Mahnaz, Barzi Dorsa, Tahooni Azadeh, Atyabi Hossein, Basir Shabestari Samira
Department of Rheumatology, Firoozgar Hospital, Rheumatology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Department of Internal Medicine, Firoozgar Hospital Research Center, Iran University of Medical Sciences, Tehran Iran.
Caspian J Intern Med. 2021 Winter;12(1):22-28. doi: 10.22088/cjim.12.1.22.
Rheumatoid arthritis (RA) is the most common chronic inflammatory joint disease. Complications of RA can cause low quality of life and disabilities. Nowadays, despite all the medical developments, etiology of RA is unclear. Both soft and hard tissue damages occur in RA and periodontitis due to chronic inflammation and also since tissue damage presentation and pathogenesis of RA and periodontitis are the same, this study was done for evaluating the relationship between clinical and laboratory findings in RA patients with their oral status and disease activity.
This case-control study was performed on 236 patients; 118 RA patients and 118 cases of normal people. Gingivitis, dental caries and plaques, oral hygiene and severity of periodontitis were measured based on gingival index, plaque index, clinical attachment level, Decayed Missing Filled index and oral hygiene index-simplified. Disease activity was assessed according to Diseases Activity Score-28. Blood samples were taken to evaluate the level of anti-CCP, RF, ESR, CRP, and CBC. Data were analyzed by t-test and chi-square.
RA patients are more susceptible to periodontitis, plaque formation and dental caries. There is a relationship among RA disease and periodontitis, oral hygiene, gingivitis. There is also a reverse relationship between RF level and periodontitis severity likewise dental caries. There is no significant relationship between other laboratory findings and the oral status of patients.
This is more likely for RA patients to experience periodontitis which can destruct alveoli bone and it can also cause early tooth loss. Regular examination and early treatment are highly recommended.
类风湿关节炎（RA）是最常见的慢性炎症性关节疾病。RA的并发症可导致生活质量低下和残疾。如今，尽管医学有了诸多发展，但RA的病因仍不清楚。由于慢性炎症，RA和牙周炎都会发生软组织和硬组织损伤，而且由于RA和牙周炎的组织损伤表现及发病机制相同，因此开展本研究以评估RA患者的临床和实验室检查结果与其口腔状况及疾病活动度之间的关系。
本病例对照研究对236名患者进行；118名RA患者和118名正常人。根据牙龈指数、菌斑指数、临床附着水平、龋失补指数和简化口腔卫生指数来测量牙龈炎、龋齿和牙菌斑、口腔卫生状况及牙周炎的严重程度。根据疾病活动度评分-28评估疾病活动度。采集血样以评估抗环瓜氨酸肽抗体（anti-CCP）、类风湿因子（RF）、红细胞沉降率（ESR）、C反应蛋白（CRP）和全血细胞计数（CBC）水平。数据采用t检验和卡方检验进行分析。
RA患者更容易患牙周炎、形成牙菌斑和龋齿。RA疾病与牙周炎、口腔卫生、牙龈炎之间存在关联。RF水平与牙周炎严重程度以及龋齿之间也存在负相关关系。其他实验室检查结果与患者口腔状况之间无显著关联。
RA患者更有可能患牙周炎，牙周炎会破坏牙槽骨，还可能导致早期牙齿脱落。强烈建议定期检查和早期治疗。
