Orhurhu Vwaire, Chu Robert, Xie Katherine, Kamanyi Ghislain N, Salisu Bisola, Salisu-Orhurhu Mariam, Urits Ivan, Kaye Rachel J, Hasoon Jamal, Viswanath Omar, Kaye Aaron J, Karri Jay, Marshall Zwade, Kaye Alan D, Anahita Dua
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Johns Hopkins School of Medicine, Baltimore, MA, USA.
Cardiol Ther. 2021 Jun;10(1):111-140. doi: 10.1007/s40119-021-00213-x. Epub 2021 Mar 11.
Chronic venous insufficiency is found to some extent in a large proportion of the world's population, especially in the elderly and obese. Despite its prevalence, little research has been pursued into this pathology when compared to similarly common conditions. Pain is often the presenting symptom of chronic venous insufficiency and has significant deleterious effects on quality of life. This manuscript will describe the development of pain in chronic venous insufficiency, and will also review both traditional methods of pain management and novel advances in both medical and surgical therapy for this disease.
Pain in chronic venous insufficiency is a common complication which remains poorly correlated in recent studies with the clinically observable extent of disease. Although lifestyle modification remains the foundation of treatment for pain associated with chronic venous sufficiency, compression devices and various pharmacologic agents have emerged as safe and effective treatments for pain in these patients. In patients for whom these measures are insufficient, recently developed minimally invasive vascular surgical techniques have been shown to reduce postsurgical complications and recovery time, although additional research is necessary to characterize long-term outcomes of these procedures. This review discusses the latest findings concerning the pathophysiology of pain in chronic venous insufficiency, conservative and medical management, and surgical strategies for pain relief, including minimally invasive treatment strategies.
在世界上很大一部分人口中都能在一定程度上发现慢性静脉功能不全,尤其是在老年人和肥胖人群中。尽管其患病率很高,但与同样常见的疾病相比,对这种病理状况的研究却很少。疼痛往往是慢性静脉功能不全的主要症状,对生活质量有重大的有害影响。本文将描述慢性静脉功能不全中疼痛的发展情况,还将回顾针对该疾病的传统疼痛管理方法以及药物和手术治疗方面的新进展。
慢性静脉功能不全中的疼痛是一种常见并发症,在最近的研究中,它与临床上可观察到的疾病程度之间的相关性仍然很差。尽管生活方式的改变仍然是与慢性静脉功能不全相关疼痛治疗的基础,但压力治疗装置和各种药物已成为这些患者疼痛的安全有效治疗方法。对于这些措施不足的患者,尽管需要更多研究来确定这些手术的长期效果,但最近开发的微创血管外科技术已被证明可以减少术后并发症并缩短恢复时间。本综述讨论了有关慢性静脉功能不全疼痛病理生理学、保守和药物治疗以及缓解疼痛的手术策略(包括微创治疗策略)的最新发现。