Yang H X, Zuo H J, Jia S J, Ye P C, Xing H R, Zhao X, Yang X Y, Zhang W Y, Song X T
Department of Comprehensive Medical, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Beijing Anzhen Hospital, Capital Medical University, Department of Community Health Research, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2021 Mar 24;49(3):242-249. doi: 10.3760/cma.j.cn112148-20200417-00324.
To observe the characteristics and trends during the last 11 years of risk factors of young adults with first acute coronary syndrome (ACS). It was a cross-sectional study. We included young adults (18 to 44 years old) hospitalized for acute coronary syndrome in Beijing Anzhen Hospital for a first time from January 2007 to December 2017. Acute coronary syndromes include ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI), and unstable angina (UA). The general information, medical history and laboratory test were recorded. Risk factors of ACS were smoking, dyslipidemia, overweight/obesity, hypertension and diabetes. Data from 7 106 patients were analyzed, mean age was (39.8±4.2) years old and 6 593(92.8%)were men, including 2 254 (31.7%) STEMI, 704 (9.9%) NSTEMI and 4 148 (58.4%) UA. Most patients were male (6 593(92.8%)). Dyslipidemia (85.8%(6 094/7 106)), overweight/obesity (82.3%(5 850/7 106)), and smoking (63.9%(4 545/7 106)) were most prevalent. 98.3% (6 885/7 106) patients had at least 1 risk factor. The prevalence of hypertension, diabetes and overweight/obesity increased from 2007 to 2017. Rates of hypertension increased from 37.1%(111/299) to 48.1%(498/1 035) (<0.01), diabetes from 12.0%(36/299) to 19.4%(201/1 035) (<0.01), overweight/obesity from 74.2%(222/299) to 83.9%(868/1 035) (<0.05), respectively. Dyslipidemia, overweight/obesity and smoking are most prevalent risk factors in young adults with a first ACS and most patients have at least 1 risk factor for ACS. Rates of hypertension, diabetes and overweight/obesity progressively increases over time in this patient cohort.
观察首次发生急性冠状动脉综合征(ACS)的青年成人危险因素在过去11年中的特征及趋势。这是一项横断面研究。我们纳入了2007年1月至2017年12月期间首次因急性冠状动脉综合征在北京安贞医院住院的青年成人(18至44岁)。急性冠状动脉综合征包括ST段抬高型心肌梗死(STEMI)、非ST段抬高型心肌梗死(NSTEMI)和不稳定型心绞痛(UA)。记录了一般信息、病史和实验室检查结果。ACS的危险因素为吸烟、血脂异常、超重/肥胖、高血压和糖尿病。对7106例患者的数据进行了分析,平均年龄为(39.8±4.2)岁,男性6593例(92.8%),其中STEMI患者2254例(31.7%),NSTEMI患者704例(9.9%),UA患者4148例(58.4%)。大多数患者为男性(6593例(92.8%))。血脂异常(85.8%(6094/7106))、超重/肥胖(82.3%(5850/7106))和吸烟(63.9%(4545/7106))最为常见。98.3%(6885/7106)的患者至少有1种危险因素。高血压、糖尿病和超重/肥胖的患病率从2007年到2017年呈上升趋势。高血压患病率从37.1%(111/299)升至48.1%(498/1035)(<0.01),糖尿病患病率从12.0%(36/299)升至19.4%(201/1035)(<0.01),超重/肥胖患病率从74.2%(222/299)升至83.9%(868/1035)(<0.05)。血脂异常、超重/肥胖和吸烟是首次发生ACS的青年成人中最常见的危险因素,且大多数患者至少有1种ACS危险因素。在该患者队列中,高血压、糖尿病和超重/肥胖的患病率随时间逐渐升高。