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内华达州和华盛顿州合法大麻花卉产品报告的四氢大麻酚(THC)浓度的频率分布在THC阈值约20%处呈不连续增加。

The frequency distribution of reported THC concentrations of legal cannabis flower products increases discontinuously around the 20% THC threshold in Nevada and Washington state.

作者信息

Zoorob Michael J

机构信息

Department of Government, Harvard University, 1737 Cambridge St, Cambridge, MA, 02138, USA.

出版信息

J Cannabis Res. 2021 Mar 14;3(1):6. doi: 10.1186/s42238-021-00064-2.

Abstract

BACKGROUND

Cannabis laboratory testing reliability is a scientific and policy challenge in US states with legal cannabis. Greater reported THC concentration yields higher prices, and media reports describe a well-known consumer and dispensary preference for flower products containing a minimum 20% THC content-an economically meaningful but biologically arbitrary threshold. This paper examines the frequency distribution of reported THC concentration in legal cannabis flower products in Nevada and Washington state for unusual shifts around the 20% threshold suggestive of potential manipulation of reported THC results.

METHODS

THC concentration test results for 142,000 Chemotype 1 flower products from Washington state between June 2014 and May 2017 and 55,000 flower products from Nevada between December 2017 and January 2020 were analyzed for changes in the frequency distribution around the 20% threshold using the McCrary density test. Analyses were performed among all labs in each state, the highest volume lab in Washington, and two labs in Washington which had their licenses suspended for testing irregularities during the study period.

RESULTS

Comparing just above the 20% THC threshold with just below it, the frequency of test results increased by about 43% in Nevada (z = 15.6, p < 0.001) and by about 17% in Washington (z = 11.0, p < 0.001). In Washington's highest volume testing lab, frequency increased by only about 1% (z = 0.39, p = 0.70), while it increased by about 47% (z = 12.7, p < 0.001) among the two suspended labs. Subset to those growers which sent products to both sets of labs, frequency of flower products just above the 20% threshold increased by 2% in Washington's largest lab (z = 0.50, p = 0.62) and by 52% among the two suspended labs (z = 12.8, p < 0.001).

DISCUSSION

There is a statistically unusual spike in the frequency of products reporting just higher than 20% THC in both states consistent with economic incentives for products to contain at least 20% THC. This "bunching" of reported THC levels exists among some, but not all, cannabis testing labs, suggesting that laboratory differences (rather than precise manipulation by growers) drive this potential manipulation in reported THC content. These findings elaborate on prior research highlighting unexplained interlaboratory variation in cannabis testing results and highlight ongoing irregularities with legal cannabis testing.

CONCLUSION

These findings highlight the need for industry oversight and cautions researchers working with reported cannabis THC concentration data, which may be biased by economic incentives to report higher THC.

摘要

背景

在美国大麻合法化的州,大麻实验室检测的可靠性是一个科学和政策方面的挑战。报告的四氢大麻酚(THC)浓度越高,价格就越高,而且媒体报道称,消费者和药房普遍偏好THC含量至少为20%的花卉产品——这是一个具有经济意义但生物学上随意设定的阈值。本文研究了内华达州和华盛顿州合法大麻花卉产品中报告的THC浓度的频率分布,以寻找在20%阈值附近的异常变化,这些变化可能暗示报告的THC结果存在潜在操纵。

方法

分析了2014年6月至2017年5月期间华盛顿州142,000种化学类型1花卉产品以及2017年12月至2020年1月期间内华达州55,000种花卉产品的THC浓度测试结果,使用麦克拉里密度检验来分析20%阈值附近频率分布的变化。在每个州的所有实验室、华盛顿州业务量最大的实验室以及华盛顿州在研究期间因检测违规而被吊销执照的两个实验室中进行了分析。

结果

将略高于20% THC阈值的测试结果与略低于该阈值的结果进行比较,内华达州测试结果的频率增加了约43%(z = 15.6,p < 0.001),华盛顿州增加了约17%(z = 11.0,p < 0.001)。在华盛顿州业务量最大的检测实验室中,频率仅增加了约1%(z = 0.39,p = 0.70),而在两个被吊销执照的实验室中增加了约47%(z = 12.7,p < 0.001)。对于那些将产品送往两组实验室的种植者,在华盛顿州最大的实验室中,略高于20%阈值的花卉产品频率增加了2%(z = 0.50,p = 0.62),在两个被吊销执照的实验室中增加了52%(z = 12.8,p < 0.001)。

讨论

在两个州中,报告的THC略高于20%的产品频率在统计上出现了异常峰值,这与产品含有至少20% THC的经济激励措施一致。这种报告的THC水平“聚集”现象在一些但并非所有大麻检测实验室中存在,这表明实验室差异(而非种植者的精确操纵)导致了报告的THC含量的这种潜在操纵。这些发现详细阐述了先前的研究,该研究强调了大麻检测结果中无法解释的实验室间差异,并突出了合法大麻检测中持续存在的违规行为。

结论

这些发现凸显了行业监管的必要性,并提醒研究人员在处理报告的大麻THC浓度数据时要谨慎,因为这些数据可能因报告更高THC的经济激励而存在偏差。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e70a/7958443/32801ab031f5/42238_2021_64_Fig1_HTML.jpg

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