不变自然杀伤T细胞的代谢：概述
Metabolism in Invariant Natural Killer T Cells: An Overview.
作者信息
Yarosz Emily L, Chang Cheong-Hee, Kumar Ajay
机构信息
Immunology Graduate Program, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
出版信息
Immunometabolism. 2021;3(2). doi: 10.20900/immunometab20210010. Epub 2021 Feb 10.
Cellular metabolism is critical for generating energy and macromolecules for cell growth and survival. In recent years, the importance of metabolism in mediating T cell differentiation, proliferation, and function has been a hot topic of investigation. However, very little is known about metabolic regulation in invariant natural killer T (iNKT) cells. In this viewpoint, we will discuss what is currently known about immunometabolism in iNKT cells and how these findings relate to CD4 T cells.
细胞代谢对于产生能量以及生成用于细胞生长和存活的大分子至关重要。近年来，代谢在介导T细胞分化、增殖和功能方面的重要性一直是研究的热点。然而，关于不变自然杀伤T（iNKT）细胞中的代谢调节，我们所知甚少。在本文观点中，我们将讨论目前已知的iNKT细胞免疫代谢情况，以及这些发现与CD4 T细胞的关系。
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