端粒酶：姜黄素在癌症治疗效果中的作用靶点。

Telomerase: A Target for Therapeutic Effects of Curcumin in Cancer.

机构信息

Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Adv Exp Med Biol. 2021;1286:135-143. doi: 10.1007/978-3-030-55035-6_10.

DOI:10.1007/978-3-030-55035-6_10

PMID:33725351

Abstract

Telomerases are attractive targets for development of new anticancer agents. Most tumors express the enzyme telomerase that maintains telomere length and thus ensures indefinite cell proliferation, a hallmark of cancer. Curcumin has been shown to be effective against several types of malignancies and has also been shown to have inhibitory effects on telomerase activity. Hence, the aim of this chapter is to review the available investigations of curcumin on telomerase activity. Based on the findings obtained from the different studies here, we conclude that the telomerase inhibitory effects of curcumin are integral to its anticancer activity, and thus curcumin may be useful therapeutically in the cancer field.

摘要

端粒酶是开发新型抗癌药物的有吸引力的靶点。大多数肿瘤表达端粒酶，这种酶维持端粒长度，从而确保无限的细胞增殖，这是癌症的一个标志。姜黄素已被证明对几种类型的恶性肿瘤有效，并且还显示对端粒酶活性有抑制作用。因此，本章的目的是综述姜黄素对端粒酶活性的研究。根据本研究中的不同研究结果，我们得出结论，姜黄素对端粒酶的抑制作用是其抗癌活性的重要组成部分，因此姜黄素在癌症领域可能具有治疗价值。