Department of Biology, Faculty of Science, Al-Hussein Bin Talal University, Ma'an 71111, Jordan; Department of Medical Analysis, Princess Aisha Bint Al-Hussein Faculty of Nursing and Health Sciences, Al-Hussein Bin Talal University, Ma'an 71111, Jordan.
Department of Medical Analysis, Princess Aisha Bint Al-Hussein Faculty of Nursing and Health Sciences, Al-Hussein Bin Talal University, Ma'an 71111, Jordan.
Biomed Pharmacother. 2021 Jun;138:111410. doi: 10.1016/j.biopha.2021.111410. Epub 2021 Mar 19.
Cardiovascular complications are the leading cause of morbidity in diabetes. Oxidative stress and inflammation are implicated in the development and progression of diabetic cardiomyopathy (DCM). This study explored the cardioprotective effect of galangin (Gal), a natural flavonoid with radical-scavenging and anti-inflammatory activities, in diabetic rats. An experimental diabetic rat model was achieved by a single injection of 50 mg/kg streptozotocin. Gal (15 mg/kg) was administered daily for six weeks and the samples were then collected. Diabetic rats exhibited hyperglycemia, increased glycosylated hemoglobin, triglycerides and cholesterol levels and reduced serum insulin. Serum troponin I, CK-MB and LDH were increased in diabetic rats. Furthermore, hearts of diabetic rats were characterized by elevated malondialdehyde, protein carbonyl, NF-κB p65, TNF-α, IL-1β, iNOS, IL-6, Bax, caspase-3 and 8-Oxo-dG, and decreased superoxide dismutase, catalase, reduced GSH, and Bcl-2. Gal ameliorated hyperglycemia, dyslipidemia, and heart function markers, and prevented histopathological alterations in diabetic rats. In addition, Gal attenuated cardiac oxidative injury, inflammation and apoptosis, and boosted antioxidant defenses. In conclusion, Gal has a protective effect on cardiomyopathy by attenuating hyperglycemia, dyslipidemia, oxidative stress and inflammation in diabetic rats.
心血管并发症是糖尿病患者发病率的主要原因。氧化应激和炎症与糖尿病心肌病（DCM）的发生和发展有关。本研究探讨了具有自由基清除和抗炎活性的天然类黄酮高良姜素（Gal）在糖尿病大鼠中的心脏保护作用。通过单次注射 50mg/kg 链脲佐菌素建立实验性糖尿病大鼠模型。Gal（15mg/kg）每日给药 6 周，然后收集样本。糖尿病大鼠表现为高血糖、糖化血红蛋白、甘油三酯和胆固醇水平升高以及血清胰岛素减少。糖尿病大鼠的血清肌钙蛋白 I、CK-MB 和 LDH 升高。此外，糖尿病大鼠的心脏表现为丙二醛、蛋白羰基、NF-κB p65、TNF-α、IL-1β、iNOS、IL-6、Bax、caspase-3 和 8-Oxo-dG 升高，超氧化物歧化酶、过氧化氢酶、还原型谷胱甘肽和 Bcl-2 减少。Gal 改善了糖尿病大鼠的高血糖、血脂异常和心脏功能标志物，并预防了其组织病理学改变。此外，Gal 减轻了心脏氧化损伤、炎症和细胞凋亡，并增强了抗氧化防御。总之，Gal 通过减轻糖尿病大鼠的高血糖、血脂异常、氧化应激和炎症对心肌病具有保护作用。
