月海在信号通路和多种疾病过程中的新作用。
Novel roles of Tsukushi in signaling pathways and multiple disease processes.
机构信息
Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai, China.
出版信息
Biofactors. 2021 Jul;47(4):512-521. doi: 10.1002/biof.1723. Epub 2021 Mar 23.
Tsukushi (TSK), a newly identified hepatokine, is a member of the small leucine-rich proteoglycans (SLRPs) family. TSK was originally isolated and identified in the lens of the chicken. Preliminary research on TSK has focused on its role in various physiological processes such as growth and development, wound healing, and cartilage formation. In recent years, the role of TSK in regulating cell signaling pathways, cell proliferation, and differentiation has been studied. In addition, the research has gradually expanded to the fields of glycolipid metabolism and energy balance. This article briefly reviews the role of TSK in the physiological and pathological process.
豆薯（TSK），一种新发现的肝分泌因子，是小富含亮氨酸的蛋白聚糖（SLRPs）家族的成员。TSK 最初在鸡的晶状体中被分离和鉴定。对 TSK 的初步研究集中在其在生长发育、伤口愈合和软骨形成等各种生理过程中的作用。近年来，TSK 在调节细胞信号通路、细胞增殖和分化中的作用已被研究。此外，研究逐渐扩展到糖脂代谢和能量平衡领域。本文简要综述了 TSK 在生理和病理过程中的作用。
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