虾青素在糖尿病肾病中的治疗潜力。

Therapeutic Potential of Astaxanthin in Diabetic Kidney Disease.

机构信息

Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Okayama, Japan.

出版信息

Adv Exp Med Biol. 2021;1261:239-248. doi: 10.1007/978-981-15-7360-6_22.

DOI:10.1007/978-981-15-7360-6_22

PMID:33783747

Abstract

Astaxanthin is a carotenoid that has potent protective effects on diabetic kidney disease (DKD) in diabetic mice models. DNA microarray study clearly demonstrated the involvement of mitochondrial oxidative phosphorylation pathway in the renal glomerular cells of diabetic mice and also showed that the expression of upregulated genes associated with this pathway was decreased by the treatment with astaxanthin. Proteomic analysis confirmed that the increases of 4-hydroxy-2-nonenal (HNE)- and N-(hexanonyl)lysine (HEL)-modified proteins were inhibited by the treatment with astaxanthin. These results demonstrated that astaxanthin exerts a protective effect against hyperglycemia-induced DKD by attenuating mitochondrial oxidative stress and subsequent cellular dysfunction.

摘要

虾青素是一种类胡萝卜素，对糖尿病小鼠模型的糖尿病肾病（DKD）具有强大的保护作用。DNA 微阵列研究清楚地表明，线粒体氧化磷酸化途径参与了糖尿病小鼠的肾小球细胞，并且还表明与该途径相关的上调基因的表达通过虾青素的治疗而降低。蛋白质组学分析证实，虾青素的治疗抑制了 4-羟基-2-壬烯醛（HNE）和 N-（己酰基）赖氨酸（HEL）修饰蛋白的增加。这些结果表明虾青素通过减轻线粒体氧化应激和随后的细胞功能障碍来发挥对抗高血糖诱导的 DKD 的保护作用。