DePhillipo Nicholas N, LaPrade Robert F, Zaffagnini Stefano, Mouton Caroline, Seil Romain, Beaufils Philippe
Oslo Sports Trauma Research Center, 4014 Ulleval Stadion, 0806, Oslo, Norway.
Twin Cities Orthopedics, Edina, MN, USA.
J Exp Orthop. 2021 Mar 31;8(1):24. doi: 10.1186/s40634-021-00345-y.
The purpose of this study was to evaluate the main focus areas for research and development for furthering the state of meniscus science in 2021.
An electronic survey including 10 questions was sent in a blind fashion to the faculty members of the 5 International Conference on Meniscus Science and Surgery. These faculty served as an expert consensus on the future of research and development areas of meniscus science. Survey responses were analyzed using descriptive statistics and ranking weighted averages were calculated to score survey questions.
Of the 82 faculty, 76 (93%) from 18 different countries completed the survey (84% male, 16% female). The highest ranked future research and development focus areas were meniscus repair, biologics, osteotomy procedures, addressing meniscus extrusion, and the development of new therapies for the prevention of posttraumatic osteoarthritis. Currently, the most 'valuable' type of biologic reported for meniscus treatment was platelet-rich plasma. The main reported global research limitation was a lack of long-term clinical outcomes data. The most promising emerging medical technologies for improving meniscus science were 3-D printing, personalized medicine, and artificial implants.
This survey suggests that the future of meniscus science should be focused on meniscal preservation techniques through meniscus repair, addressing meniscal extrusion, and the use of orthobiologics. The lack of long-term clinical outcomes was the main reported research limitation globally for meniscus treatment. Future product development utilizing emerging medical technologies suggest the use of 3-D printing for meniscal transplants/scaffolds, personalized treatment, and bioengineering for artificial implants.
Level V.
本研究旨在评估2021年推动半月板科学发展的主要研发重点领域。
一项包含10个问题的电子调查问卷以盲法发送给了5届国际半月板科学与外科学术会议的教职人员。这些教职人员就半月板科学研发领域的未来达成了专家共识。使用描述性统计方法分析调查问卷的回复,并计算排名加权平均值以对调查问题进行评分。
82名教职人员中,来自18个不同国家的76名(93%)完成了调查(男性占84%,女性占16%)。排名最高的未来研发重点领域是半月板修复、生物制剂、截骨手术、解决半月板挤压问题以及开发预防创伤后骨关节炎的新疗法。目前,报告中用于半月板治疗的最“有价值”的生物制剂类型是富血小板血浆。报告的全球主要研究局限性是缺乏长期临床结果数据。用于改善半月板科学的最有前景的新兴医疗技术是3D打印、个性化医疗和人工植入物。
本次调查表明,半月板科学的未来应聚焦于通过半月板修复、解决半月板挤压问题以及使用骨科生物制剂来进行半月板保留技术。全球范围内,缺乏长期临床结果是报告的半月板治疗主要研究局限性。利用新兴医疗技术的未来产品开发表明,3D打印可用于半月板移植/支架、个性化治疗以及人工植入物的生物工程。
V级。