Tsinghua Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, Guangdong, PR China; Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, PR China.
Shenzhen Bay Laboratory, Shenzhen 518055, Guangdong, PR China.
Biochim Biophys Acta Rev Cancer. 2021 Aug;1876(1):188534. doi: 10.1016/j.bbcan.2021.188534. Epub 2021 Mar 29.
Mitochondria, well recognized as the "powerhouse" of cells, are maternally inherited organelles with bacterial ancestry that play essential roles in a myriad of cellular functions. It has become profoundly evident that mitochondria regulate a wide array of cellular and metabolic functions, including biosynthetic metabolism, cell signaling, redox homeostasis, and cell survival. Correspondingly, defects in normal mitochondrial functioning have been implicated in various human malignancies. Cancer development involves the activation of oncogenes, inactivation of tumor suppressor genes, and impairment of apoptotic programs in cells. Mitochondria have been recognized as the site of key metabolic switches for normal cells to acquire a malignant phenotype. This review outlines the role of mitochondria in human malignancies and highlights potential aspects of mitochondrial metabolism that could be targeted for therapeutic development.
线粒体被公认为细胞的“动力工厂”，是具有细菌起源的母系遗传细胞器，在众多细胞功能中发挥着至关重要的作用。线粒体调节着广泛的细胞和代谢功能，包括合成代谢、细胞信号转导、氧化还原平衡和细胞存活，这一点已经得到了深刻的证实。相应地，正常线粒体功能的缺陷与各种人类恶性肿瘤有关。癌症的发展涉及癌基因的激活、肿瘤抑制基因的失活以及细胞凋亡程序的损害。线粒体已被认为是正常细胞获得恶性表型的关键代谢开关的位置。本综述概述了线粒体在人类恶性肿瘤中的作用，并强调了线粒体代谢的潜在方面，这些方面可能成为治疗开发的靶点。
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