B 细胞急性淋巴细胞白血病的非编码 RNA 特征。
Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia.
机构信息
Department of Biomedical and Health Sciences, University of Vermont, Burlington, VT 05405, USA.
The University of Vermont Cancer Center, University of Vermont, Burlington, VT 05405, USA.
出版信息
Int J Mol Sci. 2021 Mar 7;22(5):2683. doi: 10.3390/ijms22052683.
Non-coding RNAs (ncRNAs) comprise a diverse class of non-protein coding transcripts that regulate critical cellular processes associated with cancer. Advances in RNA-sequencing (RNA-Seq) have led to the characterization of non-coding RNA expression across different types of human cancers. Through comprehensive RNA-Seq profiling, a growing number of studies demonstrate that ncRNAs, including long non-coding RNA (lncRNAs) and microRNAs (miRNA), play central roles in progenitor B-cell acute lymphoblastic leukemia (B-ALL) pathogenesis. Furthermore, due to their central roles in cellular homeostasis and their potential as biomarkers, the study of ncRNAs continues to provide new insight into the molecular mechanisms of B-ALL. This article reviews the ncRNA signatures reported for all B-ALL subtypes, focusing on technological developments in transcriptome profiling and recently discovered examples of ncRNAs with biologic and therapeutic relevance in B-ALL.
非编码 RNA（ncRNAs）是一类广泛存在的非蛋白编码转录物，它们可以调节与癌症相关的关键细胞过程。RNA 测序（RNA-Seq）技术的进步，使得我们能够对不同类型的人类癌症中的非编码 RNA 表达进行全面分析。通过综合的 RNA-Seq 分析，越来越多的研究表明，ncRNAs（包括长非编码 RNA（lncRNA）和 microRNA（miRNA））在祖细胞 B 细胞急性淋巴细胞白血病（B-ALL）的发病机制中发挥着核心作用。此外，由于它们在细胞内稳态中的核心作用，以及作为生物标志物的潜力，ncRNAs 的研究为 B-ALL 的分子机制提供了新的见解。本文综述了所有 B-ALL 亚型的 ncRNA 特征，重点介绍了转录组分析的技术进展，以及最近发现的具有生物学和治疗相关性的 ncRNAs 实例。
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